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    Ttll1 TTL family tubulin polyglutamylase complex subunit L1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362969, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Ttll1provided by RGD
    Official Full Name
    TTL family tubulin polyglutamylase complex subunit L1provided by RGD
    Primary source
    RGD:1309124
    See related
    EnsemblRapid:ENSRNOG00000010141 AllianceGenome:RGD:1309124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PGs3
    Summary
    Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within several processes, including cerebellar Purkinje cell differentiation; mucociliary clearance; and regulation of blastocyst development. Predicted to be located in ciliary basal body. Predicted to be active in cilium. Orthologous to human TTLL1 (tubulin tyrosine ligase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 42.8), Thymus (RPKM 27.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116499536..116528833, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114619509..114648850, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124338396..124367719, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene protein kinase C and casein kinase substrate in neurons 2 Neighboring gene uncharacterized LOC120093699 Neighboring gene BCL2-interacting killer Neighboring gene uncharacterized LOC134479952 Neighboring gene malonyl-CoA-acyl carrier protein transacylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice. Suzuki H, et al. Sci Rep, 2018 Feb 13. PMID 29440671, Free PMC Article
    2. Tubulin tyrosine ligase-like 1 deficiency results in chronic rhinosinusitis and abnormal development of spermatid flagella in mice. Vogel P, et al. Vet Pathol, 2010 Jul. PMID 20442420
    3. Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. Ikegami K, et al. Proc Natl Acad Sci U S A, 2010 Jun 8. PMID 20498047, Free PMC Article
    4. Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport. Magiera MM, et al. EMBO J, 2018 Dec 3. PMID 30420556, Free PMC Article
    5. A targeted multienzyme mechanism for selective microtubule polyglutamylation. van Dijk J, et al. Mol Cell, 2007 May 11. PMID 17499049

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin-glutamic acid ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebellar Purkinje cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immune response in nasopharyngeal-associated lymphoid tissue ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mucociliary clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyglutamylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of blastocyst development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polyglutamylase complex subunit TTLL1
    Names
    probable tubulin polyglutamylase TTLL1
    tubulin polyglutamylase TTLL1
    tubulin polyglutamylase complex subunit 3
    tubulin tyrosine ligase like 1
    tubulin tyrosine ligase-like family, member 1
    tubulin--tyrosine ligase-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012200.2 → NP_001012200.1  polyglutamylase complex subunit TTLL1

      See identical proteins and their annotated locations for NP_001012200.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q5PPI9
      UniProtKB/TrEMBL
      A0A8I6G7K0
      Conserved Domains (1) summary
      pfam03133
      Location:59 → 364
      TTL; Tubulin-tyrosine ligase family

    2. NM_001393857.1 → NP_001380786.1  polyglutamylase complex subunit TTLL1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q5PPI9
      UniProtKB/TrEMBL
      A0A8I6G7K0
      Related
      ENSRNOP00000052832.4, ENSRNOT00000055978.6
      Conserved Domains (1) summary
      pfam03133
      Location:59 → 364
      TTL; Tubulin-tyrosine ligase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      116499536..116528833 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263933.1 → XP_063120003.1  polyglutamylase complex subunit TTLL1 isoform X2

    2. XM_039079601.2 → XP_038935529.1  polyglutamylase complex subunit TTLL1 isoform X4

      Conserved Domains (1) summary
      pfam03133
      Location:7 → 264
      TTL; Tubulin-tyrosine ligase family

    3. XM_063263932.1 → XP_063120002.1  polyglutamylase complex subunit TTLL1 isoform X1

      Related
      ENSRNOP00000081132.2, ENSRNOT00000110361.2

    4. XM_006242104.3 → XP_006242166.1  polyglutamylase complex subunit TTLL1 isoform X3

      See identical proteins and their annotated locations for XP_006242166.1

      UniProtKB/Swiss-Prot
      Q5PPI9
      UniProtKB/TrEMBL
      A0A8I6G7K0
      Conserved Domains (1) summary
      pfam03133
      Location:59 → 364
      TTL; Tubulin-tyrosine ligase family

    5. XM_063263935.1 → XP_063120005.1  polyglutamylase complex subunit TTLL1 isoform X3

      UniProtKB/Swiss-Prot
      Q5PPI9
      UniProtKB/TrEMBL
      A0A8I6G7K0

    6. XM_063263934.1 → XP_063120004.1  polyglutamylase complex subunit TTLL1 isoform X3

      UniProtKB/Swiss-Prot
      Q5PPI9
      UniProtKB/TrEMBL
      A0A8I6G7K0

    7. XM_063263937.1 → XP_063120007.1  polyglutamylase complex subunit TTLL1 isoform X4

    RNA

    1. XR_010053012.1 RNA Sequence

    2. XR_010053011.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PPI9.1 GenPept UniProtKB/Swiss-Prot:Q5PPI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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