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    Vgll2 vestigial-like family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309772, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Vgll2provided by RGD
    Official Full Name
    vestigial-like family member 2provided by RGD
    Primary source
    RGD:1311903
    See related
    EnsemblRapid:ENSRNOG00000000405 AllianceGenome:RGD:1311903
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein C-terminus binding activity and transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and skeletal muscle tissue development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human VGLL2 (vestigial like family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 46.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vgll2 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (31952214..31958100)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (31409529..31415408)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (33077106..33082962)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC134483808 Neighboring gene heat shock protein family D (Hsp60) member 1, pseudogene 6 Neighboring gene uncharacterized LOC134483925 Neighboring gene transforming growth factor beta regulator 1-like Neighboring gene ROS proto-oncogene 1 , receptor tyrosine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mammalian vestigial-like 2, a cofactor of TEF-1 and MEF2 transcription factors that promotes skeletal muscle differentiation. Maeda T, et al. J Biol Chem, 2002 Dec 13. PMID 12376544
    2. A Sveinsson's chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ. Kitagawa M. Biochem Biophys Res Commun, 2007 Oct 5. PMID 17689488
    3. VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Günther S, et al. Nucleic Acids Res, 2004. PMID 14762206, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription cofactor vestigial-like protein 2
    Names
    vestigial like 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107630.1 → NP_001101100.1  transcription cofactor vestigial-like protein 2

      See identical proteins and their annotated locations for NP_001101100.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474016
      UniProtKB/TrEMBL
      A6K475, D3ZG38
      Related
      ENSRNOP00000000456.3, ENSRNOT00000000456.6
      Conserved Domains (1) summary
      pfam07545
      Location:80 → 109
      Vg_Tdu; Vestigial/Tondu family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      31952214..31958100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256448.4 → XP_006256510.1  transcription cofactor vestigial-like protein 2 isoform X1

      Conserved Domains (1) summary
      pfam07545
      Location:79 → 109
      Vg_Tdu; Vestigial/Tondu family

    2. XM_008772885.3 → XP_008771107.1  transcription cofactor vestigial-like protein 2 isoform X2

      Conserved Domains (1) summary
      pfam07545
      Location:45 → 75
      Vg_Tdu; Vestigial/Tondu family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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