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    Slc43a2 solute carrier family 43 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287532, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Slc43a2provided by RGD
    Official Full Name
    solute carrier family 43 member 2provided by RGD
    Primary source
    RGD:1305819
    See related
    EnsemblRapid:ENSRNOG00000003835 AllianceGenome:RGD:1305819
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305819
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity and neutral amino acid transmembrane transporter activity. Predicted to be involved in neutral amino acid transport. Predicted to act upstream of or within L-amino acid transport and negative regulation of leucine import. Predicted to be located in plasma membrane. Orthologous to human SLC43A2 (solute carrier family 43 member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 321.7), Brain (RPKM 108.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc43a2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60873721..60919113)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (60375462..60420838)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (63676317..63719283)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Rab interacting lysosomal protein Neighboring gene scavenger receptor class F, member 1 Neighboring gene phosphatidylinositol transfer protein, alpha Neighboring gene glutathione peroxidase 4, pseudogene 2 Neighboring gene inositol polyphosphate-5-phosphatase K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of LAT4, a novel amino acid transporter with system L activity. Bodoy S, et al. J Biol Chem, 2005 Mar 25. PMID 15659399
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-isoleucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-leucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-methionine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-phenylalanine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-alpha-amino acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within L-amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isoleucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methionine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of L-leucine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phenylalanine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large neutral amino acids transporter small subunit 4
    Names
    solute carrier family 43 (amino acid system L transporter), member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105812.1 → NP_001099282.1  large neutral amino acids transporter small subunit 4

      See identical proteins and their annotated locations for NP_001099282.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HGS1, D3ZDC2
      Related
      ENSRNOP00000005100.4, ENSRNOT00000005100.6
      Conserved Domains (1) summary
      cl28910
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      60873721..60919113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085518.2 → XP_038941446.1  large neutral amino acids transporter small subunit 4 isoform X1

      UniProtKB/TrEMBL
      A6HGS1, D3ZDC2
      Conserved Domains (1) summary
      cl28910
      Location:90 → 239
      MFS; Major Facilitator Superfamily

    2. XM_063268680.1 → XP_063124750.1  large neutral amino acids transporter small subunit 4 isoform X1

      UniProtKB/TrEMBL
      A6HGS1, D3ZDC2

    3. XM_063268679.1 → XP_063124749.1  large neutral amino acids transporter small subunit 4 isoform X1

      UniProtKB/TrEMBL
      A6HGS1, D3ZDC2

    4. XM_063268681.1 → XP_063124751.1  large neutral amino acids transporter small subunit 4 isoform X2

      Related
      ENSRNOP00000105638.1, ENSRNOT00000132929.1
    Nucleotide Protein Strain
    Heading Accession and Version

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