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    Rsph6a radial spoke head 6 homolog A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292684, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Rsph6aprovided by RGD
    Official Full Name
    radial spoke head 6 homolog Aprovided by RGD
    Primary source
    RGD:1306786
    See related
    EnsemblRapid:ENSRNOG00000061526 AllianceGenome:RGD:1306786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dmwd; Rshl1; Hn1-ps1
    Summary
    Predicted to be involved in cilium assembly; cilium movement; and manchette disassembly. Predicted to be located in sperm flagellum. Predicted to be part of radial spoke. Predicted to be active in axoneme. Orthologous to human RSPH6A (radial spoke head 6 homolog A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 90.9) and Brain (RPKM 5.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rsph6a in Genome Data Viewer
    Location:
    1q21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87828779..87848483)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78700801..78720444)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (79959555..79979217)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene forkhead box A3 Neighboring gene symplekin scaffold protein Neighboring gene transfer RNA glycine (anticodon ACC) 6 Neighboring gene jupiter microtubule associated homolog 1-like Neighboring gene uncharacterized LOC108349062 Neighboring gene DM1 locus, WD repeat containing Neighboring gene DM1 protein kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sperm capacitation is associated with phosphorylation of the testis-specific radial spoke protein Rsph6a†. Paudel B, et al. Biol Reprod, 2019 Feb 1. PMID 30239614, Free PMC Article
    2. RSPH6A is required for sperm flagellum formation and male fertility in mice. Abbasi F, et al. J Cell Sci, 2018 Oct 11. PMID 30185526, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in manchette disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm flagellum assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of radial spoke head ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    radial spoke head protein 6 homolog A
    Names
    dystrophia myotonica-containing WD repeat motif
    hematological and neurological expressed 1 (Hn1-ps1) pseudogene
    radial spoke head-like protein 1
    radial spokehead-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024748.2 → NP_001019919.1  radial spoke head protein 6 homolog A isoform 2

      See identical proteins and their annotated locations for NP_001019919.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J8J2, F1MAJ7, Q4V8E8
      Conserved Domains (1) summary
      pfam04712
      Location:188 → 626
      Radial_spoke; Radial spokehead-like protein

    2. NM_001415788.1 → NP_001402717.1  radial spoke head protein 6 homolog A isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JWS7, A6J8J2
      Related
      ENSRNOP00000069999.2, ENSRNOT00000090515.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      87828779..87848483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283150.1 → XP_063139220.1  radial spoke head protein 6 homolog A isoform X1

      UniProtKB/TrEMBL
      A6J8J2

    2. XM_063283154.1 → XP_063139224.1  radial spoke head protein 6 homolog A isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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