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    Grin3b glutamate ionotropic receptor NMDA type subunit 3B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170796, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Grin3bprovided by RGD
    Official Full Name
    glutamate ionotropic receptor NMDA type subunit 3Bprovided by RGD
    Primary source
    RGD:621705
    See related
    EnsemblRapid:ENSRNOG00000012562 AllianceGenome:RGD:621705
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NR3B; GluN3B; NMDAR3B
    Summary
    Enables several functions, including glycine binding activity; neurotransmitter binding activity; and neurotransmitter receptor activity. Involved in ionotropic glutamate receptor signaling pathway. Part of NMDA selective glutamate receptor complex. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of postsynaptic density membrane. Orthologous to human GRIN3B (glutamate ionotropic receptor NMDA type subunit 3B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 21.0), Adrenal (RPKM 15.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10381495..10387817, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9730861..9737183, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12764993..12771310)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene calponin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 259 Neighboring gene WD repeat domain 18 Neighboring gene AT-rich interaction domain 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Immunolocalization of NMDA receptor subunit NR3B in selected structures in the rat forebrain, cerebellum, and lumbar spinal cord. Wee KS, et al. J Comp Neurol, 2008 Jul 1. PMID 18425811
    2. Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria. Fukumori R, et al. Neurochem Int, 2010 Dec. PMID 20813147
    3. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Chatterton JE, et al. Nature, 2002 Feb 14. PMID 11823786
    4. Circadian and developmental regulation of N-methyl-d-aspartate-receptor 1 mRNA splice variants and N-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus. Bendová Z, et al. Neuroscience, 2009 Mar 17. PMID 19361480
    5. Motoneuron-specific expression of NR3B, a novel NMDA-type glutamate receptor subunit that works in a dominant-negative manner. Nishi M, et al. J Neurosci, 2001 Dec 1. PMID 11717388, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In contrast to NR2D, NR3B expression rises gradually from postnatal day P2 to P21.
      Title: Postnatal development of N-methyl-D-aspartate receptor subunits 2A, 2B, 2C, 2D, and 3B immunoreactivity in brain stem respiratory nuclei of the rat.
    2. NMDA receptor subunit NR3B is essential for the dominant negative properties of calcium moblization into mitochondria.
      Title: Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria.
    3. The NMDAR3b subunits exhibit developmental loss around the time of eye opening in rat suprachiasmatic nucleus.
      Title: Circadian and developmental regulation of N-methyl-d-aspartate-receptor 1 mRNA splice variants and N-methyl-d-aspartate-receptor 3 subunit expression within the rat suprachiasmatic nucleus.
    4. NR3B is widely expressed in the structures examined in the rat forebrain (hippocampus, cerebral cortex, caudoputamen, and nucleus accumbens), cerebellum, and lumbar sections of the spinal cord.
      Title: Immunolocalization of NMDA receptor subunit NR3B in selected structures in the rat forebrain, cerebellum, and lumbar spinal cord.
    5. Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
      Title: Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to NMDA glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to glycine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ionotropic glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ionotropic glutamate receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ionotropic glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NMDA selective glutamate receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NMDA selective glutamate receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of NMDA selective glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutamate receptor ionotropic, NMDA 3B
    Names
    N-methyl-D-aspartate receptor subtype 3B
    glutamate [NMDA] receptor subunit 3B
    glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
    glutamate receptor, ionotropic, NMDA3B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133308.2 → NP_579842.2  glutamate receptor ionotropic, NMDA 3B precursor

      See identical proteins and their annotated locations for NP_579842.2

      Status: PROVISIONAL

      Source sequence(s)
      AF440691
      UniProtKB/Swiss-Prot
      Q8VHN2
      UniProtKB/TrEMBL
      F1LPZ6
      Related
      ENSRNOP00000017064.5, ENSRNOT00000017064.7
      Conserved Domains (3) summary
      cd06377
      Location:21 → 405
      PBP1_iGluR_NMDA_NR3; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR3 subunit of NMDA receptor family
      cd13720
      Location:414 → 808
      PBP2_iGluR_NMDA_Nr3; The ligand-binding domain of the NR3 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:576 → 842
      Lig_chan; Ligand-gated ion channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      10381495..10387817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHN2.2 GenPept UniProtKB/Swiss-Prot:Q8VHN2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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