Pla2g6 phospholipase A2 group VI [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pla2g6provided by RGD
Official Full Name: phospholipase A2 group VIprovided by RGD
Primary source: RGD:628867
See related: EnsemblRapid:ENSRNOG00000012295 AllianceGenome:RGD:628867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: iPla2; PNPLA9; GVI PLA2; caI-PLA2; iPLA2-beta
Summary: Enables several functions, including ATP-dependent protein binding activity; calcium-independent phospholipase A2 activity; and palmitoyl-CoA hydrolase activity. Involved in several processes, including cardiolipin acyl-chain remodeling; positive regulation of nitrogen compound metabolic process; and positive regulation of secretion. Located in cytosol and mitochondrion. Biomarker of pleurisy. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 165.3), Kidney (RPKM 64.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (112731803..112771978, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (110851378..110891557, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (120519479..120559716, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the transcriptional activation of nuclear factor of activated T-cell proteins (NFATs), but not nuclear factor-kappaB, by IL-1beta stimulation was markedly attenuated by the iPLA2 inhibitor bromoenol lactone, and NFATc4 knockdown markedly attenuated the IL-1beta-induced expression of both CCL2 and CXCL10.
Title: The group VIA calcium-independent phospholipase A(2) and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts.
PEDF can protect against hypoxia-induced activation of the NLRP3 inflammasome by inhibiting mitochondrial fission though PEDFR/iPLA2.
Title: PEDF Inhibits the Activation of NLRP3 Inflammasome in Hypoxia Cardiomyocytes through PEDF Receptor/Phospholipase A2.
Data suggest glucose-induced insulin secretion is first up-regulated (acute infection), then down-regulated (chronic infection) in beta cells infected with S. aureus; Pla2g4a is up-regulated in acute infection; Pla2g6 is up-regulated in chronic infection.
Title: Role of cytosolic and calcium independent phospholipases A(2) in insulin secretion impairment of INS-1E cells infected by S. aureus.
The iPLA2gamma/UCP2 synergy provides a feedback antioxidant mechanism preventing oxidative stress by physiological fatty acid intake in pancreatic beta-cells, regulating glucose-, fatty acid-, and redox-stimulated insulin secretion.
Title: H₂O₂-Activated Mitochondrial Phospholipase iPLA₂γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein-Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic β-Cells.
membrane potential sensitive activity is the iPLA2gamma
Title: The iPLA(2)γ is identified as the membrane potential sensitive phospholipase in liver mitochondria.
Leptin was shown to significantly inhibit the activity of iPLA2, which is considered to play crucial roles in non-apoptotic cell death, resulting in effective prevention of ischemia-induced myocyte death.
Title: Leptin suppresses non-apoptotic cell death in ischemic rat cardiomyocytes by reduction of iPLA(2) activity.
the mitochondrial iPLA2 may help to coordinate local capillary blood flow with changing energy demands
Title: Regulation of the Ca(2+)-independent phospholipase A2 in liver mitochondria by changes in the energetic state.
acts as an inhibitory modulator of NKCC2 activity in thick ascending limb
Title: Group VIA phospholipase A2 is a target for vasopressin signaling in the thick ascending limb.
Data show an increase of liver group VII phospholipase A2 gene expression in the obese animals together with a strong specific inhibition of type IVA and VIA phospholipases A2.
Title: The metabolic cascade leading to eicosanoid precursors--desaturases, elongases, and phospholipases A2--is altered in Zucker fatty rats.
cPLA(2) and iPLA(2) are involved in stimulating endothelial migration and proliferation in the presence of glioma conditioned culture medium.
Title: Cytosolic and calcium-independent phospholipase A(2) mediate glioma-enhanced proangiogenic activity of brain endothelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (39)

General gene information

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Markers

BM382819 (e-PCR)
- UniSTS:260901

BE108691 (e-PCR)
- UniSTS:247848

RH141625 (e-PCR)
- UniSTS:223619

BI275205 (e-PCR)
- UniSTS:249594

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-independent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-independent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-independent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-independent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acyl-CoA hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables long-chain fatty acyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables lysophospholipase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables lysophospholipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidyl phospholipase B activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	TAS Traceable Author Statement more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine hydrolase activity	IEA Inferred from Electronic Annotation more info
enables serine hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IEA Inferred from Electronic Annotation more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiolipin acyl-chain remodeling	IEA Inferred from Electronic Annotation more info
involved_in cardiolipin acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in cardiolipin acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiolipin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cardiolipin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylethanolamine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in platelet activating factor metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of arachidonic acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of arachidonic acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ceramide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase C signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of release of cytochrome c from mitochondria	IDA Inferred from Direct Assay more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
involved_in urinary bladder smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	TAS Traceable Author Statement more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in pseudopodium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 85/88 kDa calcium-independent phospholipase A2

Names: 2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; intracellular membrane-associated calcium-independent phospholipase A2 beta; palmitoyl-CoA hydrolase; patatin-like phospholipase domain-containing protein 9; phospholipase A2, group VI (cytosolic, calcium-independent)

NP_001005560.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

NP_001257725.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_006242059.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_006242060.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_006242061.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_006242064.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_006242065.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_006242066.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_006242067.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_008763979.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_038935290.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_038935291.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_063119763.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_063119764.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_063119765.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

XP_063119766.1

EC 3.1.1.4

EC 3.1.1.5

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005560.1 → NP_001005560.1 85/88 kDa calcium-independent phospholipase A2 isoform 1

See identical proteins and their annotated locations for NP_001005560.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

BC081916

UniProtKB/Swiss-Prot

G3V7M8, P97570, Q66HD1

UniProtKB/TrEMBL

A0A8L2R578

Related

ENSRNOP00000072104.2, ENSRNOT00000087344.3

Conserved Domains (5) summary

cd07212
Location:481 → 794

Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

COG0666
Location:345 → 419

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:286 → 314

ANK; ANK repeat [structural motif]

pfam12796
Location:156 → 249

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:103 → 183

Ank_2; Ankyrin repeats (3 copies)
NM_001270796.1 → NP_001257725.1 85/88 kDa calcium-independent phospholipase A2 isoform 2

See identical proteins and their annotated locations for NP_001257725.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

BC081916, JAXUCZ010000007

UniProtKB/TrEMBL

A0A8L2R578

Related

ENSRNOP00000108803.1, ENSRNOT00000121906.1

Conserved Domains (4) summary

cd07212
Location:426 → 739

Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

cd00204
Location:214 → 370

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:291 → 380

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:286 → 314

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

112731803..112771978 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242002.1 → XP_006242064.1 85/88 kDa calcium-independent phospholipase A2 isoform X4

See identical proteins and their annotated locations for XP_006242064.1

UniProtKB/TrEMBL

A0A8L2R578

Conserved Domains (5) summary

cd07212
Location:505 → 818

Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

COG0666
Location:345 → 419

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:214 → 370

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:291 → 380

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:286 → 314

ANK; ANK repeat [structural motif]
XM_006242003.1 → XP_006242065.1 85/88 kDa calcium-independent phospholipase A2 isoform X4

See identical proteins and their annotated locations for XP_006242065.1

UniProtKB/TrEMBL

A0A8L2R578

Conserved Domains (5) summary

cd07212
Location:505 → 818

Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

COG0666
Location:345 → 419

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:214 → 370

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:291 → 380

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:286 → 314

ANK; ANK repeat [structural motif]
XM_006242004.3 → XP_006242066.1 85/88 kDa calcium-independent phospholipase A2 isoform X4

See identical proteins and their annotated locations for XP_006242066.1

UniProtKB/TrEMBL

A0A8L2R578

Conserved Domains (5) summary

cd07212
Location:505 → 818

Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

COG0666
Location:345 → 419

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:214 → 370

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:291 → 380

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:286 → 314

ANK; ANK repeat [structural motif]
XM_063263695.1 → XP_063119765.1 85/88 kDa calcium-independent phospholipase A2 isoform X9

UniProtKB/Swiss-Prot

G3V7M8, P97570, Q66HD1

UniProtKB/TrEMBL

A0A8L2R578
XM_063263694.1 → XP_063119764.1 85/88 kDa calcium-independent phospholipase A2 isoform X8

UniProtKB/TrEMBL

A0A8L2Q8C9, A0A8L2R578

Related

ENSRNOP00000016827.6, ENSRNOT00000016827.8
XM_063263693.1 → XP_063119763.1 85/88 kDa calcium-independent phospholipase A2 isoform X6

UniProtKB/TrEMBL

A0A8L2R578
XM_006241998.5 → XP_006242060.1 85/88 kDa calcium-independent phospholipase A2 isoform X2

See identical proteins and their annotated locations for XP_006242060.1

UniProtKB/TrEMBL

A0A8L2R578

Conserved Domains (5) summary

cd07212
Location:523 → 836

Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

COG0666
Location:363 → 437

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:232 → 388

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:309 → 398

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:304 → 332

ANK; ANK repeat [structural motif]
XM_008765757.4 → XP_008763979.1 85/88 kDa calcium-independent phospholipase A2 isoform X5

UniProtKB/TrEMBL

A0A8L2R578

Conserved Domains (4) summary

cd07212
Location:487 → 800

Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

cd00204
Location:251 → 407

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:328 → 417

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:323 → 351

ANK; ANK repeat [structural motif]
XM_006241997.5 → XP_006242059.1 85/88 kDa calcium-independent phospholipase A2 isoform X1

UniProtKB/TrEMBL

A0A8L2R578

Related

ENSRNOP00000100746.1, ENSRNOT00000153317.1

Conserved Domains (5) summary

cd07212
Location:542 → 855

Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

COG0666
Location:382 → 456

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:251 → 407

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:328 → 417

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:323 → 351

ANK; ANK repeat [structural motif]
XM_006242005.5 → XP_006242067.1 85/88 kDa calcium-independent phospholipase A2 isoform X7

UniProtKB/TrEMBL

A0A8L2R578

Conserved Domains (4) summary

cd07212
Location:463 → 776

Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

cd00204
Location:251 → 407

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:328 → 417

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:323 → 351

ANK; ANK repeat [structural motif]
XM_006241999.5 → XP_006242061.1 85/88 kDa calcium-independent phospholipase A2 isoform X3

UniProtKB/TrEMBL

A0A8L2Q8G5, A0A8L2R578

Related

ENSRNOP00000017104.5, ENSRNOT00000017108.7

Conserved Domains (5) summary

cd07212
Location:518 → 831

Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9

COG0666
Location:382 → 456

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:251 → 407

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:328 → 417

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:323 → 351

ANK; ANK repeat [structural motif]
XM_039079363.2 → XP_038935291.1 85/88 kDa calcium-independent phospholipase A2 isoform X11

Conserved Domains (4) summary

PLN03192
Location:324 → 509

PLN03192; Voltage-dependent potassium channel; Provisional

sd00045
Location:323 → 351

ANK; ANK repeat [structural motif]

pfam12796
Location:193 → 286

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:140 → 220

Ank_2; Ankyrin repeats (3 copies)
XM_039079362.2 → XP_038935290.1 85/88 kDa calcium-independent phospholipase A2 isoform X10

Conserved Domains (4) summary

COG0666
Location:382 → 456

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:323 → 351

ANK; ANK repeat [structural motif]

pfam12796
Location:193 → 286

Ank_2; Ankyrin repeats (3 copies)

cl39094
Location:140 → 220

Ank_2; Ankyrin repeats (3 copies)
XM_063263696.1 → XP_063119766.1 85/88 kDa calcium-independent phospholipase A2 isoform X11