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    Thbs3 thrombospondin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681309, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Thbs3provided by RGD
    Official Full Name
    thrombospondin 3provided by RGD
    Primary source
    RGD:1596780
    See related
    EnsemblRapid:ENSRNOG00000059903 AllianceGenome:RGD:1596780
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heparin binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within bone trabecula formation; growth plate cartilage development; and ossification involved in bone maturation. Predicted to be located in perinuclear region of cytoplasm. Orthologous to human THBS3 (thrombospondin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 57.0), Uterus (RPKM 57.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176919549..176931357)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174621788..174633594)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188528979..188540738)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glucosylceramidase beta 1 Neighboring gene transfer RNA valine (anticodon AAC) 42 Neighboring gene Metaxin 1 Neighboring gene microRNA 92b Neighboring gene mucin 1, cell surface associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head. Hankenson KD, et al. Mol Cell Biol, 2005 Jul. PMID 15964815, Free PMC Article
    2. Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype. Armstrong DJ, et al. Int J Biochem Cell Biol, 2002 Jun. PMID 11943589
    3. Thrombospondin 3 is a developmentally regulated heparin binding protein. Qabar AN, et al. J Biol Chem, 1994 Jan 14. PMID 8288588
    4. Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Eroglu C, et al. Cell, 2009 Oct 16. PMID 19818485, Free PMC Article
    5. Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen. Posey KL, et al. Am J Pathol, 2008 Jun. PMID 18467703, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone trabecula formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within growth plate cartilage development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ossification involved in bone maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thrombospondin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305458.1 → NP_001292387.1  thrombospondin-3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2JZH3, A0A8I6G4F0
      Related
      ENSRNOP00000071047.2, ENSRNOT00000087934.3
      Conserved Domains (9) summary
      cd00054
      Location:315 → 351
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:527 → 549
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:550 → 585
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:456 → 490
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam02412
      Location:551 → 585
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:740 → 937
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:377 → 406
      EGF_3; EGF domain
      cd16079
      Location:226 → 268
      TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
      cl22861
      Location:20 → 192
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176919549..176931357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282533.1 → XP_063138603.1  thrombospondin-3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G4F0

    2. XM_039103121.2 → XP_038959049.1  thrombospondin-3 isoform X2

      UniProtKB/TrEMBL
      A6J6D1
      Conserved Domains (8) summary
      cd00054
      Location:315 → 351
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:527 → 549
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:550 → 585
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:456 → 490
      TSP3_1C; TSP3 repeat_1C [structural motif]
      cd16079
      Location:226 → 268
      TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
      pfam02412
      Location:550 → 585
      TSP_3; Thrombospondin type 3 repeat
      pfam12947
      Location:377 → 406
      EGF_3; EGF domain
      cl22861
      Location:20 → 192
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    3. XM_039103123.2 → XP_038959051.1  thrombospondin-3 isoform X1

      Conserved Domains (8) summary
      cd00054
      Location:27 → 63
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:239 → 261
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:262 → 297
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:168 → 202
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam02412
      Location:262 → 297
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:452 → 649
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:89 → 118
      EGF_3; EGF domain
      NF033845
      Location:167 → 409
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    Nucleotide Protein Strain
    Heading Accession and Version

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