Itih2 inter-alpha-trypsin inhibitor heavy chain 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itih2provided by RGD
Official Full Name: inter-alpha-trypsin inhibitor heavy chain 2provided by RGD
Primary source: RGD:1565426
See related: EnsemblRapid:ENSRNOG00000001066 AllianceGenome:RGD:1565426
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of endopeptidase activity. Predicted to be located in extracellular region. Orthologous to human ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 3143.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (73285281..73321555)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (68375574..68411849)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (72160734..72197248)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

D17Got89 (e-PCR)
- UniSTS:111721

RH139079 (e-PCR)
- UniSTS:221165

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hyaluronic acid binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hyaluronan metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inter-alpha-trypsin inhibitor heavy chain H2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.