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    Exoc1 exocyst complex component 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305287, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Exoc1provided by RGD
    Official Full Name
    exocyst complex component 1provided by RGD
    Primary source
    RGD:1304939
    See related
    EnsemblRapid:ENSRNOG00000002144 AllianceGenome:RGD:1304939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sec3l1
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; phosphatidylinositol-mediated signaling; and positive regulation of protein secretion. Predicted to act upstream of or within embryo implantation. Predicted to be located in cytoplasm and cytoplasmic side of apical plasma membrane. Predicted to be part of exocyst. Predicted to be active in plasma membrane. Orthologous to human EXOC1 (exocyst complex component 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 154.2), Spleen (RPKM 136.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    14p11
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31965782..32014156, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (31611536..31659920, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (34132210..34192296, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene ribosomal protein L23a, pseudogene 19 Neighboring gene centrosomal protein 135 Neighboring gene exocyst complex component 1 like Neighboring gene uncharacterized LOC102556008

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryo implantation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    exocyst complex component 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024770.2 → NP_001019941.2  exocyst complex component 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2JYT4, Q4V8H2
      Related
      ENSRNOP00000070781.2, ENSRNOT00000091230.3

    2. NM_001401331.1 → NP_001388260.1  exocyst complex component 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    3. NM_001401332.1 → NP_001388261.1  exocyst complex component 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014

    4. NM_001401333.1 → NP_001388262.1  exocyst complex component 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2K2V5
      Related
      ENSRNOP00000072393.2, ENSRNOT00000090470.3

    5. NM_001401334.1 → NP_001388263.1  exocyst complex component 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZLJ5

    6. NM_001401335.1 → NP_001388264.1  exocyst complex component 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      Related
      ENSRNOP00000087358.2, ENSRNOT00000116085.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      31965782..32014156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273076.1 → XP_063129146.1  exocyst complex component 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A8D1

    2. XM_039091880.2 → XP_038947808.1  exocyst complex component 1 isoform X2

      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184 → 889
      Sec3_C; Exocyst complex component Sec3

    3. XM_039091877.2 → XP_038947805.1  exocyst complex component 1 isoform X1

      Related
      ENSRNOP00000078584.2, ENSRNOT00000106895.2
      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191 → 896
      Sec3_C; Exocyst complex component Sec3

    4. XM_039091878.2 → XP_038947806.1  exocyst complex component 1 isoform X1

      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191 → 896
      Sec3_C; Exocyst complex component Sec3

    5. XM_063273075.1 → XP_063129145.1  exocyst complex component 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K2V5

    6. XM_063273077.1 → XP_063129147.1  exocyst complex component 1 isoform X5

    7. XM_063273078.1 → XP_063129148.1  exocyst complex component 1 isoform X6

    8. XM_063273080.1 → XP_063129150.1  exocyst complex component 1 isoform X9

      UniProtKB/TrEMBL
      Q4V8H2

    9. XM_063273079.1 → XP_063129149.1  exocyst complex component 1 isoform X8

      UniProtKB/TrEMBL
      Q4V8H2

    10. XM_039091886.2 → XP_038947814.1  exocyst complex component 1 isoform X7

      UniProtKB/TrEMBL
      Q4V8H2
      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      cl19950
      Location:191 → 683
      Sec3_C; Exocyst complex component Sec3

    11. XM_063273081.1 → XP_063129151.1  exocyst complex component 1 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JYT4, Q4V8H2
    Nucleotide Protein Strain
    Heading Accession and Version

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