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    Hpdl 4-hydroxyphenylpyruvate dioxygenase-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313521, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Hpdlprovided by RGD
    Official Full Name
    4-hydroxyphenylpyruvate dioxygenase-likeprovided by RGD
    Primary source
    RGD:1310014
    See related
    EnsemblRapid:ENSRNOG00000018143 AllianceGenome:RGD:1310014
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gloxd1; RGD1310014
    Summary
    Predicted to enable 4-hydroxyphenylpyruvate dioxygenase activity and metal ion binding activity. Predicted to be involved in aromatic amino acid family metabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia. Orthologous to human HPDL (4-hydroxyphenylpyruvate dioxygenase like). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See Hpdl in Genome Data Viewer
    Location:
    5q35
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135523258..135524864, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130286627..130288233, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135675826..135677432, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene testis associated actin remodelling kinase 2 Neighboring gene ribosomal protein S26 like 4 Neighboring gene target of EGR1, exonuclease Neighboring gene mutY DNA glycosylase Neighboring gene ribosomal protein S20, pseudogene 2 Neighboring gene uncharacterized LOC102550980

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 4-hydroxyphenylpyruvate dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    4-hydroxyphenylpyruvate dioxygenase-like protein
    Names
    glyoxalase domain containing 1
    glyoxalase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014068.1 → NP_001014090.1  4-hydroxyphenylpyruvate dioxygenase-like protein

      See identical proteins and their annotated locations for NP_001014090.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083702
      UniProtKB/Swiss-Prot
      Q5XIH9
      UniProtKB/TrEMBL
      A6JZB0
      Related
      ENSRNOP00000024393.2, ENSRNOT00000024393.5
      Conserved Domains (3) summary
      cd07250
      Location:158 → 363
      HPPD_C_like; C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS)
      TIGR01263
      Location:10 → 367
      4HPPD; 4-hydroxyphenylpyruvate dioxygenase
      cl14632
      Location:10 → 148
      Glo_EDI_BRP_like; This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135523258..135524864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIH9.1 GenPept UniProtKB/Swiss-Prot:Q5XIH9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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