Gnat2 G protein subunit alpha transducin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gnat2provided by RGD
Official Full Name: G protein subunit alpha transducin 2provided by RGD
Primary source: RGD:1309514
See related: EnsemblRapid:ENSRNOG00000019296 AllianceGenome:RGD:1309514
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of bitter taste; positive regulation of cytosolic calcium ion concentration; and response to light intensity. Located in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in achromatopsia 4 and color blindness. Orthologous to human GNAT2 (G protein subunit alpha transducin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 19.3), Adrenal (RPKM 7.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (198414568..198431532)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (195726371..195735866)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (210880754..210890765)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within L-glutamate import	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within background adaptation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cone retinal bipolar cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within detection of light stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of light stimulus involved in visual perception	ISO Inferred from Sequence Orthology more info
involved_in detection of light stimulus involved in visual perception	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of retina cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tissue regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phototransduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive gliosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to light intensity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to light intensity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to light stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal cone cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal cone cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinal rod cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in photoreceptor inner segment	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
is_active_in photoreceptor outer segment	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(t) subunit alpha-2

Names: guanine nucleotide binding protein (G protein), alpha transducing 2; guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2; guanine nucleotide binding protein, alpha transducing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108950.2 → NP_001102420.2 guanine nucleotide-binding protein G(t) subunit alpha-2

See identical proteins and their annotated locations for NP_001102420.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6HUX8, D4AA42

Related

ENSRNOP00000026237.4, ENSRNOT00000026237.7

Conserved Domains (1) summary

cd00066
Location:34 → 348

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

198414568..198431532

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102799.2 → XP_038958727.1 guanine nucleotide-binding protein G(t) subunit alpha-2 isoform X4

Conserved Domains (1) summary

cd00066
Location:34 → 198

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
XM_063282291.1 → XP_063138361.1 guanine nucleotide-binding protein G(t) subunit alpha-2 isoform X2
XM_039102800.2 → XP_038958728.1 guanine nucleotide-binding protein G(t) subunit alpha-2 isoform X5

Conserved Domains (1) summary

cd00066
Location:34 → 198

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
XM_039102796.2 → XP_038958724.1 guanine nucleotide-binding protein G(t) subunit alpha-2 isoform X1

UniProtKB/TrEMBL

A6HUX8, D4AA42

Conserved Domains (1) summary

cd00066
Location:34 → 348

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
XM_039102798.2 → XP_038958726.1 guanine nucleotide-binding protein G(t) subunit alpha-2 isoform X3

Conserved Domains (1) summary

cd00066
Location:32 → 281

G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
XM_063282292.1 → XP_063138362.1 guanine nucleotide-binding protein G(t) subunit alpha-2 isoform X3