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    Stap1 signal transducing adaptor family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305269, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Stap1provided by RGD
    Official Full Name
    signal transducing adaptor family member 1provided by RGD
    Primary source
    RGD:1311584
    See related
    EnsemblRapid:ENSRNOG00000002014 AllianceGenome:RGD:1311584
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Stap-1; RGD1311584
    Summary
    Predicted to enable macrophage colony-stimulating factor receptor binding activity; phosphotyrosine residue binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in several processes, including negative regulation of macrophage migration; positive regulation of cellular component organization; and regulation of phosphorylation. Predicted to act upstream of or within response to bacterium. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human STAP1 (signal transducing adaptor family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 229.8), Thymus (RPKM 111.5) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stap1 in Genome Data Viewer
    Location:
    14p21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (22301278..22336218, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (21950466..21981395, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (23575400..23604984, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 11C Neighboring gene uncharacterized LOC103692776 Neighboring gene gonadotropin releasing hormone receptor Neighboring gene ubiquitin-like modifier activating enzyme 6 Neighboring gene centromere protein C Neighboring gene actin, alpha 1, skeletal muscle, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loops govern SH2 domain specificity by controlling access to binding pockets. Kaneko T, et al. Sci Signal, 2010 May 4. PMID 20442417, Free PMC Article
    2. Induction of STAP-1 promotes neurotoxic activation of microglia. Stoecker K, et al. Biochem Biophys Res Commun, 2009 Jan 30. PMID 19100238
    3. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Ohya K, et al. Proc Natl Acad Sci U S A, 1999 Oct 12. PMID 10518561, Free PMC Article
    4. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Djouder N, et al. Mol Cell, 2007 Oct 12. PMID 17936702
    5. Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains. Masuhara M, et al. Biochem Biophys Res Commun, 2000 Feb 24. PMID 10679268

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109040

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables macrophage colony-stimulating factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of macrophage colony-stimulating factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of microglial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microglial cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal-transducing adaptor protein 1
    Names
    stem cell adaptor protein STAP-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025115.1 → NP_001020286.1  signal-transducing adaptor protein 1

      See identical proteins and their annotated locations for NP_001020286.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091249
      UniProtKB/TrEMBL
      A0A8I6ACF3, Q5BK11
      Related
      ENSRNOP00000002760.5, ENSRNOT00000002760.7
      Conserved Domains (2) summary
      cd10403
      Location:178 → 271
      SH2_STAP1; Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)
      cl17171
      Location:15 → 139
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      22301278..22336218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599182.3 → XP_017454671.1  signal-transducing adaptor protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZSB1, A6JCR9
      Related
      ENSRNOP00000081110.1, ENSRNOT00000096289.2

    2. XM_006250812.4 → XP_006250874.1  signal-transducing adaptor protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACF3
      Related
      ENSRNOP00000110149.1, ENSRNOT00000126926.1
      Conserved Domains (2) summary
      cd10403
      Location:178 → 271
      SH2_STAP1; Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)
      cl17171
      Location:15 → 139
      PH-like; Pleckstrin homology-like domain

    3. XM_017599181.2 → XP_017454670.1  signal-transducing adaptor protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACF3
    Nucleotide Protein Strain
    Heading Accession and Version

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