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    ASB11 ankyrin repeat and SOCS box containing 11 [ Homo sapiens (human) ]

    Gene ID: 140456, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ASB11provided by HGNC
    Official Full Name
    ankyrin repeat and SOCS box containing 11provided by HGNC
    Primary source
    HGNC:HGNC:17186
    See related
    Ensembl:ENSG00000165192 MIM:300626; AllianceGenome:HGNC:17186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
    Expression
    Biased expression in heart (RPKM 11.7), stomach (RPKM 1.0) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See ASB11 in Genome Data Viewer
    Location:
    Xp22.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (15281697..15315640, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (14864580..14898525, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (15299819..15333762, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L35a pseudogene 37 Neighboring gene ankyrin repeat and SOCS box containing 9 Neighboring gene Sharpr-MPRA regulatory region 14330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29447 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class A Neighboring gene PIR-FIGF readthrough Neighboring gene vascular endothelial growth factor D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The UBE2F-CRL5(ASB11)-DIRAS2 axis is an oncogene and tumor suppressor cascade in pancreatic cancer cells. Chang Y, et al. Dev Cell, 2024 May 20. PMID 38574733
    2. The novel gene asb11: a regulator of the size of the neural progenitor compartment. Diks SH, et al. J Cell Biol, 2006 Aug 14. PMID 16893969, Free PMC Article
    3. BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. Chen FY, et al. J Cell Biol, 2019 Sep 2. PMID 31387940, Free PMC Article
    4. MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. Kumar S, et al. Cell Rep, 2019 Feb 12. PMID 30759391, Free PMC Article
    5. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study reveals that different cellular stresses regulate BIK ubiquitination by ASB11 in opposing directions, which determines whether or not cells survive, and that blocking BIK degradation has the potential to be used as an anti-cancer strategy.
      Title: BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.
    2. ASB11 is a novel endoplasmic reticulum-associated ubiquitin ligase with the ability to interact and promote the ubiquitination of Ribophorin 1, an integral protein of the oligosaccharyltransferase (OST) glycosylation complex.
      Title: Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119168, MGC119169, DKFZp779E2460

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 11
    Names
    ASB-11
    ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase
    ankyrin repeat domain-containing SOCS box protein ASB11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012627.1 RefSeqGene

      Range
      4966..38909
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012428.2 → NP_001012428.1  ankyrin repeat and SOCS box protein 11 isoform b

      See identical proteins and their annotated locations for NP_001012428.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC095351, AF425642, BX537853, BX537857
      Consensus CDS
      CCDS35209.1
      UniProtKB/TrEMBL
      Q7Z670
      Related
      ENSP00000343408.4, ENST00000344384.8
      Conserved Domains (5) summary
      cd00204
      Location:45 → 162
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03728
      Location:261 → 302
      SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
      pfam12796
      Location:146 → 237
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:45 → 97
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:45 → 74
      ANK; ANK repeat [structural motif]

    2. NM_001201583.2 → NP_001188512.1  ankyrin repeat and SOCS box protein 11 isoform c

      See identical proteins and their annotated locations for NP_001188512.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform 1.
      Source sequence(s)
      AC095351, BX537857
      Consensus CDS
      CCDS56596.1
      UniProtKB/Swiss-Prot
      Q8WXH4
      Related
      ENSP00000369837.3, ENST00000380470.7
      Conserved Domains (4) summary
      cd00204
      Location:108 → 230
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03728
      Location:265 → 306
      SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
      pfam12796
      Location:150 → 241
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:148 → 176
      ANK; ANK repeat [structural motif]

    3. NM_080873.3 → NP_543149.1  ankyrin repeat and SOCS box protein 11 isoform a

      See identical proteins and their annotated locations for NP_543149.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC095351, AF425642, BX537857
      Consensus CDS
      CCDS14164.1
      UniProtKB/Swiss-Prot
      E9PEN1, Q3SYC4, Q7Z667, Q8WXH4
      UniProtKB/TrEMBL
      Q7Z670
      Related
      ENSP00000417914.1, ENST00000480796.6
      Conserved Domains (5) summary
      cd00204
      Location:66 → 183
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03728
      Location:282 → 323
      SOCS_ASB_9_11; SOCS (suppressors of cytokine signaling) box of ASB9 and 11 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
      pfam12796
      Location:167 → 258
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:66 → 118
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:66 → 95
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      15281697..15315640 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      14864580..14898525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WXH4.1 GenPept UniProtKB/Swiss-Prot:Q8WXH4

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