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    KIF3A kinesin family member 3A [ Homo sapiens (human) ]

    Gene ID: 11127, updated on 28-Oct-2024

    Summary

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    Official Symbol
    KIF3Aprovided by HGNC
    Official Full Name
    kinesin family member 3Aprovided by HGNC
    Primary source
    HGNC:HGNC:6319
    See related
    Ensembl:ENSG00000131437 MIM:604683; AllianceGenome:HGNC:6319
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLA10; KLP-20
    Summary
    Enables protein phosphatase binding activity; small GTPase binding activity; and spectrin binding activity. Involved in protein localization to cell junction and protein transport. Located in centriole; centrosome; and spindle microtubule. Part of kinesin II complex. Biomarker of silicosis. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in brain (RPKM 20.7), testis (RPKM 8.8) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF3A in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (132688812..132737546, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (133208481..133257281, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132028323..132073238, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132000651-132001178 Neighboring gene interleukin 13 Neighboring gene uncharacterized LOC105379176 Neighboring gene interleukin 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16333 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23096 Neighboring gene septin 8 Neighboring gene cyclin I family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16337 Neighboring gene Sharpr-MPRA regulatory region 2681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132150138-132150638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:132150639-132151139 Neighboring gene sosondowah ankyrin repeat domain family member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells. Liu R, et al. Cell Mol Biol (Noisy-le-grand), 2023 Aug 31. PMID 37715417
    2. A theory of evolution above the species level. Stanley SM. Proc Natl Acad Sci U S A, 1975 Feb. PMID 1054846, Free PMC Article
    3. KIF3A, a cilia structural gene on chromosome 5q31, and its polymorphisms show an association with aspirin hypersensitivity in asthma. Kim JH, et al. J Clin Immunol, 2011 Feb. PMID 20922562
    4. Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences. Kovacic MB, et al. PLoS One, 2011. PMID 21912604, Free PMC Article
    5. KIF3a promotes proliferation and invasion via Wnt signaling in advanced prostate cancer. Liu Z, et al. Mol Cancer Res, 2014 Apr. PMID 24413182, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate bladder cancer cell proliferation, migration and invasion.
      Title: CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate bladder cancer cell proliferation, migration and invasion.
    2. Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells.
      Title: Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells.
    3. Kinesin family member 3A induces related diseases via wingless-related integration site/beta-catenin signaling pathway.
      Title: Kinesin family member 3A induces related diseases via wingless-related integration site/β-catenin signaling pathway.
    4. lncRNA MIR600HG induces the proliferation and invasion of colorectal cancer cells via regulating miR-144-3p/KIF3A.
      Title: lncRNA MIR600HG induces the proliferation and invasion of colorectal cancer cells via regulating miR-144-3p/KIF3A.
    5. Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile.
      Title: Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile.
    6. Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells.
      Title: Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells.
    7. Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.
      Title: Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.
    8. Silencing of KIF3A suppressed TNBC cell proliferation by repressing the Rb-E2F signaling pathway and inhibited migration and invasion by repressing epithelial-mesenchymal transition. The tumor size was smaller and the number of lung metastatic nodules was lower in KIF3A depletion MDA-MB-231 cell xenograft mice than in the negative control group. In addition, KIF3A overexpression correlated with chemoresistance.
      Title: Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
    9. Study demonstrates that human ICK (intestinal cell kinase) that authors herein call CAPK (ciliopathy-associated protein kinase) interacts with human KIF3A and phosphorylates a conserved site Thr672 both in vitro and in vivo. Long, unstructured, non-catalytic carboxyl-terminal domain (CTD) of CAPK is required for this interaction with and phosphorylation of KIF3A
      Title: Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis.
    10. the association of KIF3A is with asthma + eczema. The presence of AR comorbidity did not increase the genetic association of KIF3A with asthma or even with asthma + eczema. Thus, asthma + eczema constitutes a distinct asthmatic phenotype characterized by an association with KIF3A SNPs, which is not strengthened by AR.
      Title: KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of kinesin family member 3A (KIF3A) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Changes of IP7 intracellular levels affect HIV-1 Gag release through modulation of AP3B1 and Kif3A interaction PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables spectrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole-centriole cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule anchoring at centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in organelle organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in plus-end-directed vesicle transport along microtubule TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein localization to cell junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary tip TAS
    Traceable Author Statement
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium TAS
    Traceable Author Statement
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    part_of kinesin II complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like protein KIF3A
    Names
    kinesin family protein 3A
    microtubule plus end-directed kinesin motor 3A

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300791.2 → NP_001287720.1  kinesin-like protein KIF3A isoform 1

      See identical proteins and their annotated locations for NP_001287720.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC004039, AK295089, AW086059, BC045542
      Consensus CDS
      CCDS75296.1
      UniProtKB/TrEMBL
      B4DHG8, E9PES4
      Related
      ENSP00000385808.1, ENST00000403231.6
      Conserved Domains (2) summary
      TIGR02168
      Location:450 → 616
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01371
      Location:13 → 345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

    2. NM_001300792.2 → NP_001287721.1  kinesin-like protein KIF3A isoform 2

      See identical proteins and their annotated locations for NP_001287721.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AB209780, AC004039, AW086059, BC045542
      Consensus CDS
      CCDS75295.1
      UniProtKB/TrEMBL
      B4DHG8, J3KPF9
      Related
      ENSP00000368009.1, ENST00000378735.5
      Conserved Domains (2) summary
      TIGR02168
      Location:358 → 592
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01371
      Location:13 → 345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

    3. NM_007054.7 → NP_008985.3  kinesin-like protein KIF3A isoform 3

      See identical proteins and their annotated locations for NP_008985.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AB209780, AC004039, AK313359, AW086059, BC020890
      Consensus CDS
      CCDS34235.1
      UniProtKB/Swiss-Prot
      A8MSW9, Q59EN1, Q86XE9, Q9Y496, Q9Y6V4
      UniProtKB/TrEMBL
      B4DHG8
      Related
      ENSP00000368020.3, ENST00000378746.8
      Conserved Domains (2) summary
      TIGR02168
      Location:340 → 589
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01371
      Location:13 → 345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      132688812..132737546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008996.3 → XP_016864485.1  kinesin-like protein KIF3A isoform X2

      UniProtKB/TrEMBL
      B4DHG8

    2. XM_006714526.5 → XP_006714589.1  kinesin-like protein KIF3A isoform X1

      UniProtKB/TrEMBL
      B4DHG8
      Conserved Domains (4) summary
      cd01371
      Location:13 → 345
      KISc_KIF3; Kinesin motor domain, kinesins II or KIF3_like proteins
      pfam00225
      Location:20 → 345
      Kinesin; Kinesin motor domain
      cd16269
      Location:597 → 608
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:448 → 611
      GBP_C; Guanylate-binding protein, C-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      133208481..133257281 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351517.1 → XP_054207492.1  kinesin-like protein KIF3A isoform X1

    2. XM_054351518.1 → XP_054207493.1  kinesin-like protein KIF3A isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y496.4 GenPept UniProtKB/Swiss-Prot:Q9Y496

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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