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    CMKLR1 chemerin chemokine-like receptor 1 [ Homo sapiens (human) ]

    Gene ID: 1240, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CMKLR1provided by HGNC
    Official Full Name
    chemerin chemokine-like receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:2121
    See related
    Ensembl:ENSG00000174600 MIM:602351; AllianceGenome:HGNC:2121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DEZ; ERV1; RVER1; ChemR23; CHEMERINR
    Summary
    Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; positive regulation of macrophage chemotaxis; and regulation of calcium-mediated signaling. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen (RPKM 14.3), placenta (RPKM 10.1) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CMKLR1 in Genome Data Viewer
    Location:
    12q23.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108288046..108339311, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108256268..108307509, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (108681823..108733088, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903078 Neighboring gene DNA dC->dU-editing enzyme APOBEC-3G-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:108697351-108697872 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:108699443-108699964 Neighboring gene Sharpr-MPRA regulatory region 8395 Neighboring gene Sharpr-MPRA regulatory region 632 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108732521-108733144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108739700-108740200 Neighboring gene MPRA-validated peak1933 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:108780158-108781357 Neighboring gene Sharpr-MPRA regulatory region 8786 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:108811567-108812766 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:108835174-108835930 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:108835931-108836688 Neighboring gene MPRA-validated peak1935 silencer Neighboring gene long intergenic non-protein coding RNA 1498 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:108906844-108907029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108910488-108910988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108910989-108911489 Neighboring gene FIC domain protein adenylyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus. Li XM, et al. Ann Endocrinol (Paris), 2015 Feb. PMID 25627894
    2. Assessment of CMKLR1 level in colorectal cancer and its correlation with angiogenic markers. Kiczmer P, et al. Exp Mol Pathol, 2020 Apr. PMID 31926977
    3. The serum biomarker chemerin promotes tumorigenesis and metastasis in oral squamous cell carcinoma. Lu Z, et al. Clin Sci (Lond), 2019 Mar 15. PMID 30804218
    4. Serum chemerin levels are negatively associated with male fertility and reproductive hormones. Bobjer J, et al. Hum Reprod, 2018 Dec 1. PMID 30304526
    5. Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis: Results of a Population-Based Study. Zylla S, et al. Arterioscler Thromb Vasc Biol, 2018 Jul. PMID 29853566, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma.
      Title: GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma.
    2. Association of Single Nucleotide Polymorphisms (SNPs) of Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to Allergic Rhinitis.
      Title: Association of Single Nucleotide Polymorphisms (SNPs) of Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to Allergic Rhinitis.
    3. Stable Binding of Full-Length Chemerin Is Driven by Negative Charges in the CMKLR1 N Terminus.
      Title: Stable Binding of Full-Length Chemerin Is Driven by Negative Charges in the CMKLR1 N Terminus.
    4. ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression.
      Title: ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression.
    5. [Chemerin mediated neutrophil infiltration in oral squamous cell carcinoma and predicted poor prognosis].
      Title: [Chemerin mediated neutrophil infiltration in oral squamous cell carcinoma and predicted poor prognosis].
    6. Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses.
      Title: Up-regulation of CMKLR1 in endometriosis and its relationship with inflammatory responses.
    7. Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin.
      Title: Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin.
    8. Involvement of chemerin and CMKLR1 in the progesterone decrease by PCOS granulosa cells.
      Title: Involvement of chemerin and CMKLR1 in the progesterone decrease by PCOS granulosa cells.
    9. Expression of Resistin, Chemerin, and Chemerin's Receptor in the Unstable Carotid Atherosclerotic Plaque.
      Title: Expression of Resistin, Chemerin, and Chemerin's Receptor in the Unstable Carotid Atherosclerotic Plaque.
    10. The Concentration of CMKLR1 Expression on Clinicopathological Parameters of Colorectal Cancer: A Preliminary Study.
      Title: The Concentration of CMKLR1 Expression on Clinicopathological Parameters of Colorectal Cancer: A Preliminary Study.
    Submit: New GeneRIF Correction See all GeneRIFs (63)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog
    Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
    EBI GWAS Catalog
    Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy.
    EBI GWAS Catalog
    Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
    EBI GWAS Catalog
    Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of chemokine-like receptor 1 (CMKLR1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 isolates showing CCR3 tropism are particularly efficient in using CMKLR1/ChemR23 as a co-receptor; some HIV-2 and SIV isolates also use CMKLR1/ChemR23 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126105, MGC126106

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables adipokinetic hormone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adipokinetic hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chemokine receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables complement receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-12 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of macrophage chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of macrophage chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in skeletal system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    chemerin-like receptor 1
    Names
    G-protein coupled receptor ChemR23
    G-protein coupled receptor DEZ
    chemerin receptor
    chemokine receptor-like 1
    chemokine-like receptor 1
    orphan G-protein coupled receptor, Dez
    resolvin E1 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142343.2 → NP_001135815.1  chemerin-like receptor 1 isoform a

      See identical proteins and their annotated locations for NP_001135815.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC009729, AC063957, BC106927, DA466082
      Consensus CDS
      CCDS44965.1
      UniProtKB/Swiss-Prot
      A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789
      UniProtKB/TrEMBL
      Q05KQ8
      Related
      ENSP00000449716.1, ENST00000550402.6
      Conserved Domains (1) summary
      cd15116
      Location:41 → 327
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001142344.2 → NP_001135816.1  chemerin-like receptor 1 isoform a

      See identical proteins and their annotated locations for NP_001135816.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. It encodes isoform a.
      Source sequence(s)
      AC009729, AC063957, AK291800
      Consensus CDS
      CCDS44965.1
      UniProtKB/Swiss-Prot
      A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789
      UniProtKB/TrEMBL
      Q05KQ8
      Related
      ENSP00000311733.7, ENST00000312143.11
      Conserved Domains (1) summary
      cd15116
      Location:41 → 327
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001142345.2 → NP_001135817.1  chemerin-like receptor 1 isoform a

      See identical proteins and their annotated locations for NP_001135817.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. It encodes isoform a.
      Source sequence(s)
      AC009729, AC063957, DA939526
      Consensus CDS
      CCDS44965.1
      UniProtKB/Swiss-Prot
      A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789
      UniProtKB/TrEMBL
      Q05KQ8
      Related
      ENSP00000401293.1, ENST00000412676.5
      Conserved Domains (1) summary
      cd15116
      Location:41 → 327
      7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_004072.3 → NP_004063.1  chemerin-like receptor 1 isoform b

      See identical proteins and their annotated locations for NP_004063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding sequence, compared to variant 1. It encodes isoform b, which has a shorter N-terminus than isoform a.
      Source sequence(s)
      AC009729, DA466082, U79527
      Consensus CDS
      CCDS41829.1
      UniProtKB/TrEMBL
      Q05KQ8
      Related
      ENSP00000447579.1, ENST00000552995.5
      Conserved Domains (1) summary
      pfam00001
      Location:55 → 314
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      108288046..108339311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428313.1 → XP_047284269.1  chemerin-like receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      108256268..108307509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371128.1 → XP_054227103.1  chemerin-like receptor 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K6Y5, O75748, Q3KP37, Q5U0H0, Q99788, Q99789
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99788.2 GenPept UniProtKB/Swiss-Prot:Q99788

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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