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    TPRG1 tumor protein p63 regulated 1 [ Homo sapiens (human) ]

    Gene ID: 285386, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TPRG1provided by HGNC
    Official Full Name
    tumor protein p63 regulated 1provided by HGNC
    Primary source
    HGNC:HGNC:24759
    See related
    Ensembl:ENSG00000188001 AllianceGenome:HGNC:24759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM79B
    Summary
    Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in esophagus (RPKM 2.6), skin (RPKM 1.9) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TPRG1 in Genome Data Viewer
    Location:
    3q28
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (188997227..189325304)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (191813855..192142070)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (188889760..189043093)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 11355 Neighboring gene NANOG hESC enhancer GRCh37_chr3:188674939-188675473 Neighboring gene TPRG1 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:188740290-188740806 Neighboring gene ENOPH1 pseudogene 1 Neighboring gene uncharacterized LOC107986167 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:188845804-188847003 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:188849592-188850791 Neighboring gene NANOG hESC enhancer GRCh37_chr3:188855097-188855598 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:188884267-188885466 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:188956266-188957465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20977 Neighboring gene TPRG1 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20979 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:189041855-189043054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20981 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:189166776-189167320 Neighboring gene uncharacterized LOC105374270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20982 Neighboring gene TAp63 promoter of tumor protein p63 Neighboring gene tumor protein p63 Neighboring gene DeltaNp63 promoter of tumor protein p63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14997 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:189526229-189526775 Neighboring gene microRNA 944

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tumor protein P63 Regulated 1 contributes to inflammation and cell proliferation of cystitis glandularis through regulating the NF-кB/cyclooxygenase-2/prostaglandin E2 axis. Hong T, et al. Bosn J Basic Med Sci, 2022 Feb 1. PMID 34998360, Free PMC Article
    2. Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study. Evangelou E, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jan 5. PMID 19475631, Free PMC Article
    3. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. Cheng CY, et al. Am J Hum Genet, 2013 Aug 8. PMID 24144296, Free PMC Article
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tumor protein P63 Regulated 1 contributes to inflammation and cell proliferation of cystitis glandularis through regulating the NF-small ka, CyrillicB/cyclooxygenase-2/prostaglandin E2 axis.
      Title: Tumor protein P63 Regulated 1 contributes to inflammation and cell proliferation of cystitis glandularis through regulating the NF-кB/cyclooxygenase-2/prostaglandin E2 axis.
    2. Meta-analysis of gene-disease association. (HuGE Navigator)
      Title: Non-replication of association for six polymorphisms from meta-analysis of genome-wide association studies of Parkinson's disease: large-scale collaborative study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41238, FLJ43694, MGC126599, MGC126601

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tumor protein p63-regulated gene 1 protein
    Names
    family with sequence similarity 79, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198485.4 → NP_940887.1  tumor protein p63-regulated gene 1 protein

      See identical proteins and their annotated locations for NP_940887.1

      Status: VALIDATED

      Source sequence(s)
      AC104669, AC112909, AK125682, BC101550, CR737485
      Consensus CDS
      CCDS3292.1
      UniProtKB/Swiss-Prot
      Q6ZUI0
      Related
      ENSP00000341031.3, ENST00000345063.8
      Conserved Domains (1) summary
      pfam12456
      Location:70 → 170
      hSac2; Inositol phosphatase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      188997227..189325304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448032.1 → XP_047303988.1  tumor protein p63-regulated gene 1 protein isoform X1

    2. XM_047448034.1 → XP_047303990.1  tumor protein p63-regulated gene 1 protein isoform X1

    3. XM_047448028.1 → XP_047303984.1  tumor protein p63-regulated gene 1 protein isoform X1

    4. XM_047448030.1 → XP_047303986.1  tumor protein p63-regulated gene 1 protein isoform X1

    5. XM_047448041.1 → XP_047303997.1  tumor protein p63-regulated gene 1 protein isoform X1

    6. XM_047448029.1 → XP_047303985.1  tumor protein p63-regulated gene 1 protein isoform X1

    7. XM_047448038.1 → XP_047303994.1  tumor protein p63-regulated gene 1 protein isoform X1

    8. XM_047448039.1 → XP_047303995.1  tumor protein p63-regulated gene 1 protein isoform X1

    9. XM_047448037.1 → XP_047303993.1  tumor protein p63-regulated gene 1 protein isoform X1

    10. XM_047448031.1 → XP_047303987.1  tumor protein p63-regulated gene 1 protein isoform X1

    11. XM_024453477.2 → XP_024309245.1  tumor protein p63-regulated gene 1 protein isoform X1

      Conserved Domains (1) summary
      pfam12456
      Location:70 → 190
      hSac2; Inositol phosphatase

    12. XM_047448035.1 → XP_047303991.1  tumor protein p63-regulated gene 1 protein isoform X1

    13. XM_047448040.1 → XP_047303996.1  tumor protein p63-regulated gene 1 protein isoform X1

    14. XM_047448033.1 → XP_047303989.1  tumor protein p63-regulated gene 1 protein isoform X1

    15. XM_047448036.1 → XP_047303992.1  tumor protein p63-regulated gene 1 protein isoform X1

    16. XM_011512732.3 → XP_011511034.2  tumor protein p63-regulated gene 1 protein isoform X1

      Conserved Domains (1) summary
      pfam12456
      Location:70 → 190
      hSac2; Inositol phosphatase

    17. XM_005247388.5 → XP_005247445.1  tumor protein p63-regulated gene 1 protein isoform X7

      Conserved Domains (1) summary
      pfam12456
      Location:78 → 109
      hSac2; Inositol phosphatase

    18. XM_011512736.4 → XP_011511038.1  tumor protein p63-regulated gene 1 protein isoform X6

      Conserved Domains (1) summary
      pfam12456
      Location:78 → 109
      hSac2; Inositol phosphatase

    19. XM_005247382.6 → XP_005247439.1  tumor protein p63-regulated gene 1 protein isoform X2

      Conserved Domains (1) summary
      pfam12456
      Location:78 → 178
      hSac2; Inositol phosphatase

    20. XM_011512735.4 → XP_011511037.1  tumor protein p63-regulated gene 1 protein isoform X4

      Conserved Domains (1) summary
      pfam12456
      Location:78 → 108
      hSac2; Inositol phosphatase

    21. XM_011512734.4 → XP_011511036.1  tumor protein p63-regulated gene 1 protein isoform X3

      Conserved Domains (1) summary
      pfam12456
      Location:78 → 178
      hSac2; Inositol phosphatase

    22. XM_017006263.1 → XP_016861752.1  tumor protein p63-regulated gene 1 protein isoform X5

    23. XM_047448042.1 → XP_047303998.1  tumor protein p63-regulated gene 1 protein isoform X5

    RNA

    1. XR_001740120.3 RNA Sequence

    2. XR_007095667.1 RNA Sequence

    3. XR_007095668.1 RNA Sequence

    4. XR_007095669.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      191813855..192142070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346339.1 → XP_054202314.1  tumor protein p63-regulated gene 1 protein isoform X1

    2. XM_054346337.1 → XP_054202312.1  tumor protein p63-regulated gene 1 protein isoform X1

    3. XM_054346340.1 → XP_054202315.1  tumor protein p63-regulated gene 1 protein isoform X1

    4. XM_054346338.1 → XP_054202313.1  tumor protein p63-regulated gene 1 protein isoform X1

    5. XM_054346342.1 → XP_054202317.1  tumor protein p63-regulated gene 1 protein isoform X1

    6. XM_054346345.1 → XP_054202320.1  tumor protein p63-regulated gene 1 protein isoform X1

    7. XM_054346348.1 → XP_054202323.1  tumor protein p63-regulated gene 1 protein isoform X1

    8. XM_054346346.1 → XP_054202321.1  tumor protein p63-regulated gene 1 protein isoform X1

    9. XM_054346343.1 → XP_054202318.1  tumor protein p63-regulated gene 1 protein isoform X1

    10. XM_054346344.1 → XP_054202319.1  tumor protein p63-regulated gene 1 protein isoform X1

    11. XM_054346349.1 → XP_054202324.1  tumor protein p63-regulated gene 1 protein isoform X1

    12. XM_054346347.1 → XP_054202322.1  tumor protein p63-regulated gene 1 protein isoform X1

    13. XM_054346341.1 → XP_054202316.1  tumor protein p63-regulated gene 1 protein isoform X1

    14. XM_054346351.1 → XP_054202326.1  tumor protein p63-regulated gene 1 protein isoform X3

    15. XM_054346356.1 → XP_054202331.1  tumor protein p63-regulated gene 1 protein isoform X7

    16. XM_054346355.1 → XP_054202330.1  tumor protein p63-regulated gene 1 protein isoform X6

    17. XM_054346350.1 → XP_054202325.1  tumor protein p63-regulated gene 1 protein isoform X2

    18. XM_054346352.1 → XP_054202327.1  tumor protein p63-regulated gene 1 protein isoform X4

    19. XM_054346354.1 → XP_054202329.1  tumor protein p63-regulated gene 1 protein isoform X5

    20. XM_054346353.1 → XP_054202328.1  tumor protein p63-regulated gene 1 protein isoform X5

    RNA

    1. XR_007074062.1 RNA Sequence

    2. XR_007074061.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZUI0.1 GenPept UniProtKB/Swiss-Prot:Q6ZUI0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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