TLE4 TLE family member 4, transcriptional corepressor [Homo sapiens (human)] - Gene

Summary

Official Symbol: TLE4provided by HGNC
Official Full Name: TLE family member 4, transcriptional corepressorprovided by HGNC
Primary source: HGNC:HGNC:11840
See related: Ensembl:ENSG00000106829 MIM:605132; AllianceGenome:HGNC:11840
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ESG; BCE1; ESG4; GRG4; BCE-1; Grg-4; E(spI); E(spl)
Summary: Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis (RPKM 39.3), bone marrow (RPKM 12.0) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q21.31

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (79571965..79726882)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (91730341..91885229)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (82186880..82341797)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation.
Title: TLE4 regulates muscle stem cell quiescence and skeletal muscle differentiation.
Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population.
Title: Polymorphisms of TGFB1, TLE4 and MUC22 are associated with childhood asthma in Chinese population.
the loss of TLE4 confers proliferative advantage to leukemic cells, simultaneous with an upregulation of a pro- inflammatory signature mediated through aberrant increases in Wnt signaling activity
Title: TLE4 regulation of wnt-mediated inflammation underlies its role as a tumor suppressor in myeloid leukemia.
the results suggested that TLE4, a potential prognostic biomarker for colorectal cancer, plays an important role in the development and progression of human colorectal cancer.
Title: TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway.
PPM1B interacts with Groucho 4 and is localized to DNA in a Groucho-dependent manner, and phosphatase activity is required for transcriptional silencing.
Title: The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.
Groucho related gene Grg4 robustly activates the expression of a BMP reporter gene, as well as enhancing and sustaining the upregulation of the endogenous Id1 gene induced by BMP7.
Title: The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling.
Displacing coactivators CREB-binding protein/p300 while promoting the recruitment of a corepressor, Grg4.
Title: SUMOylated SoxE factors recruit Grg4 and function as transcriptional repressors in the neural crest.
Grg4 recruits the arginine methyltransferase PRMT5 to chromatin resulting in symmetric H4R3 dimethylation.
Title: Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
Title: Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
Observational study of gene-disease association. (HuGE Navigator)
Title: Analyses of shared genetic factors between asthma and obesity in children.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH44484 (e-PCR)
- UniSTS:56323

TLE4 (e-PCR)
- UniSTS:505977

RH78181 (e-PCR)
- UniSTS:64383

RH122563 (e-PCR)
- UniSTS:138627

STS-N23632 (e-PCR)
- UniSTS:57234

SHGC-155150 (e-PCR)
- UniSTS:184980

G17366 (e-PCR)
- UniSTS:78547

TLE4_2138 (e-PCR)
- UniSTS:281059

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transducin-like enhancer protein 4

Names: B lymphocyte gene 1; enhancer of split groucho 4; groucho-related protein 4; transducin like enhancer of split 4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 4, homolog of Drosophila E(sp1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282748.2 → NP_001269677.1 transducin-like enhancer protein 4 isoform 1

See identical proteins and their annotated locations for NP_001269677.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL353813, AL358975, AL445252

Consensus CDS

CCDS65069.1

UniProtKB/Swiss-Prot

Q04727

Related

ENSP00000365720.4, ENST00000376537.8

Conserved Domains (4) summary

COG2319
Location:511 → 803

WD40; WD40 repeat [General function prediction only]

cd00200
Location:518 → 802

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 138

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:522 → 561

7WD40; WD40 repeat [structural motif]
NM_001282749.2 → NP_001269678.1 transducin-like enhancer protein 4 isoform 2

See identical proteins and their annotated locations for NP_001269678.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AL353813, AL358975

Consensus CDS

CCDS65070.1

UniProtKB/Swiss-Prot

Q04727

Related

ENSP00000265284.6, ENST00000265284.10

Conserved Domains (4) summary

COG2319
Location:454 → 746

WD40; WD40 repeat [General function prediction only]

cd00200
Location:461 → 745

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 109

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:465 → 504

7WD40; WD40 repeat [structural motif]
NM_001282753.2 → NP_001269682.1 transducin-like enhancer protein 4 isoform 4

See identical proteins and their annotated locations for NP_001269682.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks three alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 4 which is shorter than isoform 1.

Source sequence(s)

AL353813, AL358975, AL445252

Consensus CDS

CCDS75851.1

UniProtKB/Swiss-Prot

Q04727

Related

ENSP00000365727.4, ENST00000376544.7

Conserved Domains (3) summary

cd00200
Location:417 → 701

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:421 → 460

7WD40; WD40 repeat [structural motif]

pfam03920
Location:8 → 138

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001282760.2 → NP_001269689.1 transducin-like enhancer protein 4 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate exon in the 5' UTR and lacks an alternate in-frame exon in the coding region which results in the use of a downstream start codon compared to variant 1. It encodes isoform 5 which has a shorter N-terminus compared the isoform 1.

Source sequence(s)

AL353813, AL358975, AL445252

Conserved Domains (3) summary

COG2319
Location:364 → 650

WD40; WD40 repeat [General function prediction only]

cd00200
Location:365 → 649

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:369 → 408

7WD40; WD40 repeat [structural motif]
NM_001351541.2 → NP_001338470.1 transducin-like enhancer protein 4 isoform 6

Status: VALIDATED

Source sequence(s)

AL353813, AL358975, AL445252

Conserved Domains (3) summary

cd00200
Location:499 → 783

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:503 → 542

7WD40; WD40 repeat [structural motif]

pfam03920
Location:8 → 151

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001351542.2 → NP_001338471.1 transducin-like enhancer protein 4 isoform 7

Status: VALIDATED

Source sequence(s)

AL353813, AL358975, AL445252

Conserved Domains (3) summary

cd00200
Location:487 → 771

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:491 → 530

7WD40; WD40 repeat [structural motif]

pfam03920
Location:8 → 139

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001351543.2 → NP_001338472.1 transducin-like enhancer protein 4 isoform 8

Status: VALIDATED

Source sequence(s)

AK296342, AL353813, BC059405, DB284195, HY012218, HY054961

Consensus CDS

CCDS94424.1

UniProtKB/TrEMBL

A0A994J7T6

Related

ENSP00000516378.1, ENST00000706431.1

Conserved Domains (3) summary

cd00200
Location:485 → 769

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:489 → 528

7WD40; WD40 repeat [structural motif]

pfam03920
Location:10 → 137

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001351546.2 → NP_001338475.1 transducin-like enhancer protein 4 isoform 9

Status: VALIDATED

Source sequence(s)

AK296342, AL353813, BC059405, HY012218, HY054961

Conserved Domains (3) summary

cd00200
Location:484 → 768

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:488 → 527

7WD40; WD40 repeat [structural motif]

pfam03920
Location:10 → 136

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001351547.2 → NP_001338476.1 transducin-like enhancer protein 4 isoform 10

Status: VALIDATED

Source sequence(s)

AK296342, AL353813, HY012218

Conserved Domains (3) summary

cd00200
Location:469 → 753

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:473 → 512

7WD40; WD40 repeat [structural motif]

pfam03920
Location:10 → 121

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001351550.2 → NP_001338479.1 transducin-like enhancer protein 4 isoform 11

Status: VALIDATED

Source sequence(s)

AL353813, AL358975, AL445252

Conserved Domains (3) summary

cd00200
Location:466 → 750

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:470 → 509

7WD40; WD40 repeat [structural motif]

pfam03920
Location:8 → 118

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001351552.2 → NP_001338481.1 transducin-like enhancer protein 4 isoform 12

Status: VALIDATED

Source sequence(s)

AL353813, AL358975, AL445252

Conserved Domains (3) summary

cd00200
Location:465 → 749

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:469 → 508

7WD40; WD40 repeat [structural motif]

pfam03920
Location:8 → 117

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001351556.2 → NP_001338485.1 transducin-like enhancer protein 4 isoform 13

Status: VALIDATED

Source sequence(s)

AK296342, AL353813, BC059405, HY012218, HY054961

Conserved Domains (3) summary

cd00200
Location:463 → 747

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:467 → 506

7WD40; WD40 repeat [structural motif]

pfam03920
Location:10 → 115

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001351558.2 → NP_001338487.1 transducin-like enhancer protein 4 isoform 14

Status: VALIDATED

Source sequence(s)

AL353813, AL358975

Conserved Domains (3) summary

cd00200
Location:462 → 746

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:466 → 505

7WD40; WD40 repeat [structural motif]

pfam03920
Location:8 → 103

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001351560.2 → NP_001338489.1 transducin-like enhancer protein 4 isoform 15

Status: VALIDATED

Source sequence(s)

AK296342, AL353813, BI462045, HY012218, HY054961

Conserved Domains (3) summary

cd00200
Location:460 → 744

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:464 → 503

7WD40; WD40 repeat [structural motif]

pfam03920
Location:10 → 101

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001351562.2 → NP_001338491.1 transducin-like enhancer protein 4 isoform 16

Status: VALIDATED

Source sequence(s)

AL353813, AL358975

Conserved Domains (4) summary

cd00200
Location:410 → 694

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:414 → 453

7WD40; WD40 repeat [structural motif]

pfam03920
Location:8 → 109

TLE_N; Groucho/TLE N-terminal Q-rich domain

cl26464
Location:239 → 316

Atrophin-1; Atrophin-1 family
NM_001351563.2 → NP_001338492.1 transducin-like enhancer protein 4 isoform 17

Status: VALIDATED

Source sequence(s)

AK296342, AL353813, BI462045, BU428571, HY012218, HY054961

Conserved Domains (3) summary

cd00200
Location:408 → 692

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:412 → 451

7WD40; WD40 repeat [structural motif]

pfam03920
Location:10 → 107

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001351564.2 → NP_001338493.1 transducin-like enhancer protein 4 isoform 18

Status: VALIDATED

Source sequence(s)

AL353813, AL358975

Conserved Domains (3) summary

cd00200
Location:392 → 676

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:396 → 435

7WD40; WD40 repeat [structural motif]

pfam03920
Location:8 → 109

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_007005.6 → NP_008936.2 transducin-like enhancer protein 4 isoform 3

See identical proteins and their annotated locations for NP_008936.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.

Source sequence(s)

AL353813, AL358975, AL445252

Consensus CDS

CCDS43837.1

UniProtKB/Swiss-Prot

F8W6T6, Q04727, Q3ZCS1, Q5T1Y2, Q6PCB3, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9

Related

ENSP00000365735.2, ENST00000376552.8

Conserved Domains (4) summary

COG2319
Location:479 → 771

WD40; WD40 repeat [General function prediction only]

cd00200
Location:486 → 770

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 138

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:490 → 529

7WD40; WD40 repeat [structural motif]

RNA

NR_104239.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL353813, AL358975, AL445252

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

79571965..79726882

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011518952.2 → XP_011517254.1 transducin-like enhancer protein 4 isoform X1

Conserved Domains (4) summary

COG2319
Location:578 → 870

WD40; WD40 repeat [General function prediction only]

cd00200
Location:585 → 869

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:589 → 628

7WD40; WD40 repeat [structural motif]
XM_006717264.2 → XP_006717327.1 transducin-like enhancer protein 4 isoform X5

Conserved Domains (4) summary

COG2319
Location:553 → 845

WD40; WD40 repeat [General function prediction only]

cd00200
Location:560 → 844

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:564 → 603

7WD40; WD40 repeat [structural motif]
XM_011518958.2 → XP_011517260.1 transducin-like enhancer protein 4 isoform X8

Conserved Domains (4) summary

COG2319
Location:546 → 838

WD40; WD40 repeat [General function prediction only]

cd00200
Location:553 → 837

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:557 → 596

7WD40; WD40 repeat [structural motif]
XM_006717268.2 → XP_006717331.1 transducin-like enhancer protein 4 isoform X13

Conserved Domains (4) summary

COG2319
Location:521 → 813

WD40; WD40 repeat [General function prediction only]

cd00200
Location:528 → 812

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:532 → 571

7WD40; WD40 repeat [structural motif]
XM_011518967.2 → XP_011517269.1 transducin-like enhancer protein 4 isoform X20

Conserved Domains (4) summary

COG2319
Location:495 → 787

WD40; WD40 repeat [General function prediction only]

cd00200
Location:502 → 786

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:506 → 545

7WD40; WD40 repeat [structural motif]
XM_017015074.2 → XP_016870563.1 transducin-like enhancer protein 4 isoform X24
XM_011518969.2 → XP_011517271.1 transducin-like enhancer protein 4 isoform X23

Conserved Domains (4) summary

COG2319
Location:477 → 769

WD40; WD40 repeat [General function prediction only]

cd00200
Location:484 → 768

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:488 → 527

7WD40; WD40 repeat [structural motif]
XM_047423820.1 → XP_047279776.1 transducin-like enhancer protein 4 isoform X25
XM_011518956.2 → XP_011517258.1 transducin-like enhancer protein 4 isoform X6

Conserved Domains (4) summary

COG2319
Location:550 → 842

WD40; WD40 repeat [General function prediction only]

cd00200
Location:557 → 841

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 152

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:561 → 600

7WD40; WD40 repeat [structural motif]
XM_047423819.1 → XP_047279775.1 transducin-like enhancer protein 4 isoform X21
XM_011518957.2 → XP_011517259.1 transducin-like enhancer protein 4 isoform X7

Conserved Domains (4) summary

COG2319
Location:549 → 841

WD40; WD40 repeat [General function prediction only]

cd00200
Location:556 → 840

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 151

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:560 → 599

7WD40; WD40 repeat [structural motif]
XM_011518959.2 → XP_011517261.1 transducin-like enhancer protein 4 isoform X9

Conserved Domains (4) summary

COG2319
Location:537 → 829

WD40; WD40 repeat [General function prediction only]

cd00200
Location:544 → 828

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 139

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:548 → 587

7WD40; WD40 repeat [structural motif]
XM_011518965.2 → XP_011517267.1 transducin-like enhancer protein 4 isoform X18

Conserved Domains (4) summary

COG2319
Location:505 → 797

WD40; WD40 repeat [General function prediction only]

cd00200
Location:512 → 796

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 139

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:516 → 555

7WD40; WD40 repeat [structural motif]
XM_047423823.1 → XP_047279779.1 transducin-like enhancer protein 4 isoform X28
XM_011518960.2 → XP_011517262.1 transducin-like enhancer protein 4 isoform X10

Conserved Domains (4) summary

COG2319
Location:536 → 828

WD40; WD40 repeat [General function prediction only]

cd00200
Location:543 → 827

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 138

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:547 → 586

7WD40; WD40 repeat [structural motif]
XM_011518966.2 → XP_011517268.1 transducin-like enhancer protein 4 isoform X19

Conserved Domains (4) summary

COG2319
Location:504 → 796

WD40; WD40 repeat [General function prediction only]

cd00200
Location:511 → 795

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 138

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:515 → 554

7WD40; WD40 repeat [structural motif]
XM_017015083.2 → XP_016870572.1 transducin-like enhancer protein 4 isoform X29
XM_011518963.2 → XP_011517265.1 transducin-like enhancer protein 4 isoform X16

Conserved Domains (2) summary

cd00200
Location:519 → 803

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:523 → 562

7WD40; WD40 repeat [structural motif]
XM_011518964.2 → XP_011517266.1 transducin-like enhancer protein 4 isoform X17

Conserved Domains (4) summary

COG2319
Location:511 → 803

WD40; WD40 repeat [General function prediction only]

cd00200
Location:518 → 802

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 109

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:522 → 561

7WD40; WD40 repeat [structural motif]
XM_011518955.2 → XP_011517257.1 transducin-like enhancer protein 4 isoform X4

Conserved Domains (4) summary

COG2319
Location:557 → 849

WD40; WD40 repeat [General function prediction only]

cd00200
Location:564 → 848

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 112

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:568 → 607

7WD40; WD40 repeat [structural motif]
XM_011518961.2 → XP_011517263.1 transducin-like enhancer protein 4 isoform X14

Conserved Domains (4) summary

COG2319
Location:516 → 808

WD40; WD40 repeat [General function prediction only]

cd00200
Location:523 → 807

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 118

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:527 → 566

7WD40; WD40 repeat [structural motif]
XM_011518962.2 → XP_011517264.1 transducin-like enhancer protein 4 isoform X15

Conserved Domains (4) summary

COG2319
Location:515 → 807

WD40; WD40 repeat [General function prediction only]

cd00200
Location:522 → 806

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 117

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:526 → 565

7WD40; WD40 repeat [structural motif]
XM_011518968.2 → XP_011517270.1 transducin-like enhancer protein 4 isoform X22

Conserved Domains (4) summary

COG2319
Location:491 → 783

WD40; WD40 repeat [General function prediction only]

cd00200
Location:498 → 782

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 83

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:502 → 541

7WD40; WD40 repeat [structural motif]
XM_047423821.1 → XP_047279777.1 transducin-like enhancer protein 4 isoform X26
XM_011518954.2 → XP_011517256.1 transducin-like enhancer protein 4 isoform X3

Conserved Domains (4) summary

COG2319
Location:563 → 855

WD40; WD40 repeat [General function prediction only]

cd00200
Location:570 → 854

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:8 → 118

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:574 → 613

7WD40; WD40 repeat [structural motif]
XM_017015068.2 → XP_016870557.1 transducin-like enhancer protein 4 isoform X12
XM_011518970.4 → XP_011517272.1 transducin-like enhancer protein 4 isoform X30

Conserved Domains (2) summary

pfam03920
Location:8 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:589 → 628

7WD40; WD40 repeat [structural motif]
XM_047423824.1 → XP_047279780.1 transducin-like enhancer protein 4 isoform X31
XM_011518953.3 → XP_011517255.1 transducin-like enhancer protein 4 isoform X2

Conserved Domains (4) summary

COG2319
Location:576 → 868

WD40; WD40 repeat [General function prediction only]

cd00200
Location:583 → 867

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam03920
Location:13 → 131

TLE_N; Groucho/TLE N-terminal Q-rich domain

sd00039
Location:587 → 626

7WD40; WD40 repeat [structural motif]
XM_017015067.2 → XP_016870556.1 transducin-like enhancer protein 4 isoform X11
XM_047423822.1 → XP_047279778.1 transducin-like enhancer protein 4 isoform X27
XM_011518972.4 → XP_011517274.1 transducin-like enhancer protein 4 isoform X32

Conserved Domains (2) summary

cd00200
Location:228 → 512

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:232 → 271

7WD40; WD40 repeat [structural motif]