CYP4F2 cytochrome P450 family 4 subfamily F member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CYP4F2provided by HGNC
Official Full Name: cytochrome P450 family 4 subfamily F member 2provided by HGNC
Primary source: HGNC:HGNC:2645
See related: Ensembl:ENSG00000186115 MIM:604426; AllianceGenome:HGNC:2645
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CPF2
Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
Expression: Biased expression in liver (RPKM 63.5), small intestine (RPKM 42.7) and 2 other tissues See more
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Genomic context

Location:: 19p13.12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (15878023..15898074, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (16009384..16029310, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (15988833..16008884, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional Characterization of 29 Cytochrome P450 4F2 Variants Identified in a Population of 8380 Japanese Subjects and Assessment of Arachidonic Acid omega-Hydroxylation.
Title: Functional Characterization of 29 Cytochrome P450 4F2 Variants Identified in a Population of 8380 Japanese Subjects and Assessment of Arachidonic Acid ω-Hydroxylation.
Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 polymorphisms and acute ischemic stroke.
Title: Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX rs11676382 polymorphisms and acute ischemic stroke.
Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes related to the metabolism of Warfarin in healthy donors from Cali, Colombia.
Title: Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes related to the metabolism of Warfarin in healthy donors from Cali, Colombia.
CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.
Title: CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.
Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact.
Title: Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact.
The frequency of cytochrome 4F2 rs2108622 genetic variant and its effects on the lipid profile and complications of type II diabetes among a sample of patients in Jordan: A pilot study.
Title: The frequency of cytochrome 4F2 rs2108622 genetic variant and its effects on the lipid profile and complications of type II diabetes among a sample of patients in Jordan: A pilot study.
Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population.
Title: Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population.
CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non-Small Cell Lung Cancer.
Title: CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non-Small Cell Lung Cancer.
The association study between CYP20A1, CYP4F2, CYP2D6 gene polymorphisms and coronary heart disease risk in the Han population in southern China.
Title: The association study between CYP20A1, CYP4F2, CYP2D6 gene polymorphisms and coronary heart disease risk in the Han population in southern China.
Blood direct PCR: impact of CYP2C19 and CYP4F2 variants for bleeding prediction in ST-elevation myocardial infarction patients with ticagrelor.
Title: Blood direct PCR: impact of CYP2C19 and CYP4F2 variants for bleeding prediction in ST-elevation myocardial infarction patients with ticagrelor.

Submit: New GeneRIF Correction See all GeneRIFs (118)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide assessment of variability in human serum metabolism. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of acenocoumarol maintenance dosage. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies common variants associated with circulating vitamin E levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482394

SHGC-12532 (e-PCR)
- UniSTS:41569

SHGC-12532 (e-PCR)
- UniSTS:23514

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 20-aldehyde-leukotriene B4 20-monooxygenase activity	TAS Traceable Author Statement more info
enables 20-hydroxy-leukotriene B4 omega oxidase activity	TAS Traceable Author Statement more info
enables alkane 1-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha-tocopherol omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate epoxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables arachidonate omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables leukotriene-B4 20-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables leukotriene-B4 20-monooxygenase activity	TAS Traceable Author Statement more info
enables long-chain fatty acid omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	TAS Traceable Author Statement more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in blood coagulation	TAS Traceable Author Statement more info	PubMed
involved_in epoxygenase P450 pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid omega-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in icosanoid metabolic process	TAS Traceable Author Statement more info
involved_in leukotriene B4 catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in leukotriene metabolic process	TAS Traceable Author Statement more info
involved_in long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in menaquinone catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of icosanoid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in omega-hydroxylase P450 pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in omega-hydroxylase P450 pathway	TAS Traceable Author Statement more info
involved_in phylloquinone catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phylloquinone catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of icosanoid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pressure natriuresis	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal water homeostasis	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion homeostasis	IEP Inferred from Expression Pattern more info	PubMed
involved_in very long-chain fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin E metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin K catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytochrome P450 4F2

Names: 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; CYPIVF2; arachidonic acid omega-hydroxylase; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; cytochrome P450-LTB-omega; docosahexaenoic acid omega-hydroxylase; leukotriene-B(4) 20-monooxygenase 1; leukotriene-B(4) omega-hydroxylase 1; phylloquinone omega-hydroxylase CYP4F2

NP_001073.3

EC 1.14.14.1

EC 1.14.14.78

EC 1.14.14.79

EC 1.14.14.94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.