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    ARPC5L actin related protein 2/3 complex subunit 5 like [ Homo sapiens (human) ]

    Gene ID: 81873, updated on 28-Oct-2024

    Summary

    Official Symbol
    ARPC5Lprovided by HGNC
    Official Full Name
    actin related protein 2/3 complex subunit 5 likeprovided by HGNC
    Primary source
    HGNC:HGNC:23366
    See related
    Ensembl:ENSG00000136950 AllianceGenome:HGNC:23366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARC16-2
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Located in extracellular exosome and focal adhesion. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 7.9), testis (RPKM 7.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARPC5L in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124862130..124877733)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137060438..137076046)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127624409..127640012)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20268 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127618044-127618212 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127620824-127621106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127621747-127622248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127622249-127622748 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127623737-127624360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127634813-127635313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127643063-127643616 Neighboring gene WD repeat domain 38 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127646402-127646543 Neighboring gene ribosomal protein L35 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127662503-127663016 Neighboring gene golgin A1 Neighboring gene RNA, U4 small nuclear 82, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127665639-127666139 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127681363-127681624 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127702954-127703454 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127703455-127703955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28998 Neighboring gene suppressor of cancer cell invasion Neighboring gene frataxin pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3038

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    actin-related protein 2/3 complex subunit 5-like protein
    Names
    arp2/3 complex 16 kDa subunit 2
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030978.3NP_112240.1  actin-related protein 2/3 complex subunit 5-like protein

      See identical proteins and their annotated locations for NP_112240.1

      Status: VALIDATED

      Source sequence(s)
      AA731112, AK056174, AL354928
      Consensus CDS
      CCDS6859.1
      UniProtKB/Swiss-Prot
      Q7Z523, Q9BPX5
      UniProtKB/TrEMBL
      A0A024R897, B3KPC7
      Related
      ENSP00000345361.2, ENST00000353214.6
      Conserved Domains (1) summary
      pfam04699
      Location:9151
      P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      124862130..124877733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423941.1XP_047279897.1  actin-related protein 2/3 complex subunit 5-like protein isoform X3

    2. XM_047423939.1XP_047279895.1  actin-related protein 2/3 complex subunit 5-like protein isoform X2

    3. XM_047423938.1XP_047279894.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1

    RNA

    1. XR_007061359.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      137060438..137076046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363918.1XP_054219893.1  actin-related protein 2/3 complex subunit 5-like protein isoform X1