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    FBXO10 F-box protein 10 [ Homo sapiens (human) ]

    Gene ID: 26267, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FBXO10provided by HGNC
    Official Full Name
    F-box protein 10provided by HGNC
    Primary source
    HGNC:HGNC:13589
    See related
    Ensembl:ENSG00000147912 MIM:609092; AllianceGenome:HGNC:13589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX10; PRMT11
    Summary
    Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in testis (RPKM 5.1), thyroid (RPKM 4.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FBXO10 in Genome Data Viewer
    Location:
    9p13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (37510892..37576380, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (37534560..37600086, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37510889..37576377, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:37477128-37478327 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:37485410-37486001 Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 3 Neighboring gene ribosomal protein L21 pseudogene 83 Neighboring gene RNA polymerase I subunit E Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:37511563-37512119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:37515395-37515896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28396 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28400 Neighboring gene MPRA-validated peak7234 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28401 Neighboring gene Sharpr-MPRA regulatory region 11948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19910 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:37600233-37600415 Neighboring gene translocase of outer mitochondrial membrane 5 Neighboring gene FERM and PDZ domain containing 1 Neighboring gene RAB1C, member RAS oncogene family (pseudogene)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL. Guo F, et al. Leukemia, 2020 Feb. PMID 31570756
    2. Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF). Xu X, et al. Mol Carcinog, 2014 Apr. PMID 23138933, Free PMC Article
    3. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans. Wolf SS. Cell Mol Life Sci, 2009 Jul. PMID 19300908, Free PMC Article
    4. FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA. Ju UI, et al. Biochem Biophys Res Commun, 2015 Sep 4. PMID 26187670
    5. FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women. Barnholtz-Sloan JS, et al. Carcinogenesis, 2010 Aug. PMID 20554749, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL.
      Title: Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL.
    2. siRNA-mediated knockdown of FBXO11 facilitated HIF-1alpha expression in various cancer cells and HIF-1alpha-driven gene expressions, but the FBXO10 knockdown did not.
      Title: FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA.
    3. Higher Fbxo10 expression in T cells is associated with Mcs5a increased susceptibility alleles
      Title: Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF).
    4. FBXO10, a protein related to DRE-1, binds BCL2 and promotes its degradation, thereby initiating cell death. Moreover, some diffuse large B-cell lymphomas have inactivating mutations in FBXO10 or express FBXO10 at low levels.
      Title: Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41992, MGC149840

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box only protein 10
    Names
    F-box protein Fbx10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012166.3 → NP_036298.2  F-box only protein 10

      See identical proteins and their annotated locations for NP_036298.2

      Status: VALIDATED

      Source sequence(s)
      AB209610, AF174598, AI475671, AL513165, BU623815, CN411883
      Consensus CDS
      CCDS47966.1
      UniProtKB/Swiss-Prot
      Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3
      UniProtKB/TrEMBL
      Q59F51
      Related
      ENSP00000403802.2, ENST00000432825.7
      Conserved Domains (2) summary
      pfam12937
      Location:6 → 49
      F-box-like
      pfam13229
      Location:464 → 610
      Beta_helix; Right handed beta helix region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      37510892..37576380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423220.1 → XP_047279176.1  F-box only protein 10 isoform X2

      UniProtKB/Swiss-Prot
      Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3

    2. XM_047423219.1 → XP_047279175.1  F-box only protein 10 isoform X1

    3. XM_017014619.2 → XP_016870108.1  F-box only protein 10 isoform X2

      UniProtKB/Swiss-Prot
      Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3
      UniProtKB/TrEMBL
      Q59F51
      Conserved Domains (2) summary
      pfam12937
      Location:6 → 49
      F-box-like
      pfam13229
      Location:464 → 610
      Beta_helix; Right handed beta helix region

    4. XM_047423221.1 → XP_047279177.1  F-box only protein 10 isoform X2

      UniProtKB/Swiss-Prot
      Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3

    5. XM_005251439.6 → XP_005251496.2  F-box only protein 10 isoform X3

    6. XM_047423222.1 → XP_047279178.1  F-box only protein 10 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      37534560..37600086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362723.1 → XP_054218698.1  F-box only protein 10 isoform X2

      UniProtKB/Swiss-Prot
      Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3

    2. XM_054362721.1 → XP_054218696.1  F-box only protein 10 isoform X1

    3. XM_054362722.1 → XP_054218697.1  F-box only protein 10 isoform X2

      UniProtKB/Swiss-Prot
      Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3

    4. XM_054362724.1 → XP_054218699.1  F-box only protein 10 isoform X2

      UniProtKB/Swiss-Prot
      Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3

    5. XM_054362725.1 → XP_054218700.1  F-box only protein 10 isoform X3

    6. XM_054362726.1 → XP_054218701.1  F-box only protein 10 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UK96.3 GenPept UniProtKB/Swiss-Prot:Q9UK96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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