Myl7 myosin, light polypeptide 7, regulatory [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myl7provided by MGI
Official Full Name: myosin, light polypeptide 7, regulatoryprovided by MGI
Primary source: MGI:MGI:107495
See related: Ensembl:ENSMUSG00000020469 AllianceGenome:MGI:107495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MLC2a; MYL2A; RLC-A; Mylc2a; MLC-2alpha
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in cardiac muscle tissue development and heart contraction. Located in dendritic spine. Is expressed in several structures, including gastrocnemius muscle; heart; liver; uterus; and vascular system. Orthologous to human MYL7 (myosin light chain 7). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in heart adult (RPKM 358.9), lung adult (RPKM 59.1) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 11 A1; 11 3.88 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (5846637..5848782, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (5896637..5898782, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice.
Title: Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice.
these studies reveal a critical role for NMIIA-mediated contractile forces in maintaining multicellularity during sprouting.
Title: Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting.
contact guidance is preserved following loss of NM2B and that expression of NM2A alone is sufficient to establish an appropriate orientation of the cells.
Title: The role of nonmuscle myosin 2A and 2B in the regulation of mesenchymal cell contact guidance.
ata indicate that NM2A filaments are partitioned by the dynamic movements of actin fibres to which they are bound
Title: Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments.
The similarities in Eng-/- and Mlc2a-/- embryos suggest that Eng-/- mice may suffer from a primary heart developmental defect and secondary defects in vessel patterning.
Title: Cardiovascular Patterning as Determined by Hemodynamic Forces and Blood Vessel Genetics.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130995 (e-PCR)
- UniSTS:214278

Mylc2a (e-PCR), detects polymorphism
- UniSTS:143965

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiac muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart contraction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in A band	IEA Inferred from Electronic Annotation more info
located_in A band	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin regulatory light chain 2, atrial isoform

Names: MLC-2a; myosin light chain 2a; myosin light chain, regulatory A; myosin regulatory light chain 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.