MET1 uroporphyrinogen-III C-methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MET1
Official Full Name: uroporphyrinogen-III C-methyltransferase
Primary source: SGD:S000001777
Locus tag: YKR069W
See related: AllianceGenome:SGD:S000001777; FungiDB:YKR069W; VEuPathDB:YKR069W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MET20
Summary: Enables uroporphyrin-III C-methyltransferase activity. Involved in siroheme biosynthetic process. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MET1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (571612..573393)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables uroporphyrin-III C-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables uroporphyrin-III C-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables uroporphyrin-III C-methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in porphyrin-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in siroheme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in siroheme biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in siroheme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sulfate assimilation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: uroporphyrinogen-III C-methyltransferase

NP_012995.3

EC 2.1.1.107

S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

571612..573393

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179859.3 → NP_012995.3 TPA: uroporphyrinogen-III C-methyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012995.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXD0, P36150

UniProtKB/TrEMBL

G2WI97

Conserved Domains (2) summary

COG0007
Location:323 → 566

CysG; Uroporphyrinogen-III methylase (siroheme synthase) [Coenzyme transport and metabolism]

COG1648
Location:5 → 288

CysG2; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and metabolism]