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    UIP5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853918, updated on 22-Aug-2024

    Summary

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    Official Symbol
    UIP5
    Primary source
    SGD:S000001752
    Locus tag
    YKR044W
    See related
    AllianceGenome:SGD:S000001752; FungiDB:YKR044W; VEuPathDB:YKR044W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable mannose binding activity. Predicted to be involved in Golgi organization; endoplasmic reticulum organization; and endoplasmic reticulum to Golgi vesicle-mediated transport. Located in nuclear envelope. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human LMAN2 (lectin, mannose binding 2) and LMAN2L (lectin, mannose binding 2 like). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (522015..523346)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene SUN family protein UTH1 Neighboring gene sedoheptulose-bisphosphatase Neighboring gene uncharacterized protein Neighboring gene Pln1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Ulp1, an Smt3-specific protease, associates with nucleoporins. Takahashi Y, et al. J Biochem, 2000 Nov. PMID 11056382
    2. The Saccharomyces cerevisiae RAD9, RAD17 and RAD24 genes are required for suppression of mutagenic post-replicative repair during chronic DNA damage. Murakami-Sekimata A, et al. DNA Repair (Amst), 2010 Jul 1. PMID 20472512, Free PMC Article
    3. Complete DNA sequence of yeast chromosome XI. Dujon B, et al. Nature, 1994 Jun 2. PMID 8196765
    4. Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum. Colomina N, et al. J Biol Chem, 2008 Oct 17. PMID 18667435, Free PMC Article
    5. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Uip5p
    NP_012970.3
    • hypothetical protein that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      522015..523346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179834.3 → NP_012970.3  TPA: Uip5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012970.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXA6, P36137
      UniProtKB/TrEMBL
      B3LRC4, N1P0H9
      Conserved Domains (1) summary
      cd07308
      Location:55 → 320
      lectin_leg-like; legume-like lectins: ERGIC-53, ERGL, VIP36, VIPL, EMP46, and EMP47
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36137.1

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