RCN1 Rcn1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: RCN1
Official Full Name: Rcn1p
Primary source: SGD:S000001642
Locus tag: YKL159C
See related: AllianceGenome:SGD:S000001642; FungiDB:YKL159C; VEuPathDB:YKL159C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables calcium-dependent protein serine/threonine phosphatase regulator activity and protein phosphatase 2B binding activity. Involved in calcium-mediated signaling. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human RCAN3 (RCAN family member 3); RCAN1 (regulator of calcineurin 1); and RCAN2 (regulator of calcineurin 2). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The authors find that increased dosage of either RCN1 or RSA3 improves tolerance of S288C and M2 to toxic levels of ethanol.
Title: Identification of RCN1 and RSA3 as ethanol-tolerant genes in Saccharomyces cerevisiae using a high copy barcoded library.
identify the molecular mechanism of Rcn1 phosphorylation-induced stimulation of the phosphatase activity of calcineurin
Title: The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein phosphatase 2B binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IC Inferred by Curator more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

NP_012763.1

Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region