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    RPS27A ribosomal 40S subunit protein S27A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853700, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RPS27A
    Official Full Name
    ribosomal 40S subunit protein S27A
    Primary source
    SGD:S000001639
    Locus tag
    YKL156W
    See related
    AllianceGenome:SGD:S000001639; FungiDB:YKL156W; VEuPathDB:YKL156W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    A structural constituent of ribosome. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Located in cytoplasm. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 17. Orthologous to human RPS27 (ribosomal protein S27) and RPS27L (ribosomal protein S27 like). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RPS27A in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    2
    Sequence:
    Chromosome: XI; NC_001143.9 (158613..159212)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Rcn1p Neighboring gene metallo-aminopeptidase Neighboring gene tRNA methyltransferase RSM22 Neighboring gene Signal recognition particle receptor subunit beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of Rrp7p, an essential yeast protein involved in pre-rRNA processing and ribosome assembly. Baudin-Baillieu A, et al. Mol Cell Biol, 1997 Sep. PMID 9271380, Free PMC Article
    2. Genetic and biochemical characterization of antisuppressor mutants in the yeast Saccharomyces cerevisiae. Ishiguro J. Curr Genet, 1981 Dec. PMID 24185993
    3. Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation. Young BD, et al. Biochemistry, 2012 Jun 26. PMID 22650761, Free PMC Article
    4. Transfer of Ho endonuclease and Ufo1 to the proteasome by the UbL-UbA shuttle protein, Ddi1, analysed by complex formation in vitro. Voloshin O, et al. PLoS One, 2012. PMID 22815701, Free PMC Article
    5. Protein topography of the 40 S ribosomal subunit from Saccharomyces cerevisiae as shown by chemical cross-linking. Yeh YC, et al. J Biol Chem, 1986 Oct 25. PMID 3533916

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A methylated cysteine residue at position 39 of S. cerevisiae Rps27a is demonstrated in a small ribosomal subunit zinc-cysteine cluster.
      Title: Identification of methylated proteins in the yeast small ribosomal subunit: a role for SPOUT methyltransferases in protein arginine methylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ribosomal small subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal small subunit assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S27A
    NP_012766.1
    • Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      158613..159212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179722.1 → NP_012766.1  TPA: ribosomal 40S subunit protein S27A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012766.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VX42, P35997
      UniProtKB/TrEMBL
      A6ZZG7, C8ZC18, G2WHN4
      Conserved Domains (1) summary
      cl00897
      Location:5 → 82
      Ribosomal_S27e; Ribosomal protein S27
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35997.1

    Gene LinkOut

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