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    ZRT1 high-affinity Zn(2+) transporter ZRT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852637, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZRT1
    Official Full Name
    high-affinity Zn(2+) transporter ZRT1
    Primary source
    SGD:S000003224
    Locus tag
    YGL255W
    See related
    AllianceGenome:SGD:S000003224; FungiDB:YGL255W; VEuPathDB:YGL255W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables high-affinity zinc transmembrane transporter activity. Involved in zinc ion import across plasma membrane. Located in plasma membrane. Orthologous to human SLC39A1 (solute carrier family 39 member 1); SLC39A2 (solute carrier family 39 member 2); and SLC39A3 (solute carrier family 39 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ZRT1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (20978..22108)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase ADH4 Neighboring gene ncRNA Neighboring gene Fzf1p Neighboring gene hexokinase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation. Zhao H, et al. Proc Natl Acad Sci U S A, 1996 Mar 19. PMID 8637895, Free PMC Article
    2. ZRT1 Harbors an Excess of Nonsynonymous Polymorphism and Shows Evidence of Balancing Selection in Saccharomyces cerevisiae. Engle EK, et al. G3 (Bethesda), 2013 Apr 9. PMID 23550117, Free PMC Article
    3. Zinc-induced inactivation of the yeast ZRT1 zinc transporter occurs through endocytosis and vacuolar degradation. Gitan RS, et al. J Biol Chem, 1998 Oct 30. PMID 9786854
    4. A cytosolic domain of the yeast Zrt1 zinc transporter is required for its post-translational inactivation in response to zinc and cadmium. Gitan RS, et al. J Biol Chem, 2003 Oct 10. PMID 12893829
    5. The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae. Zhao H, et al. J Biol Chem, 1996 Sep 20. PMID 8798516

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the high-affinity zinc transporter ZRT1 showed an elevated rate of synonymous polymorphism indicative of balancing selection; the high rate of synonymous polymorphism coincided with nonsynonymous divergence among three haplotype groups, among which we found no detectable differences in ZRT1 function.
      Title: ZRT1 Harbors an Excess of Nonsynonymous Polymorphism and Shows Evidence of Balancing Selection in Saccharomyces cerevisiae.
    2. In yeast, zinc is transported by the transporters ZRT1 and ZRT2, which are both regulated by the zinc-responsive transcription factor ZAP1.
      Title: Modeling regulation of zinc uptake via ZIP transporters in yeast and plant roots.
    3. revealed that minisatellite alterations in a Deltazrt1 mutant occur by a combination of RAD52-dependent and RAD52-independent mechanisms
      Title: Minisatellite alterations in ZRT1 mutants occur via RAD52-dependent and RAD52-independent mechanisms in quiescent stationary phase yeast cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables high-affinity zinc transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables high-affinity zinc transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transition metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in zinc ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high-affinity Zn(2+) transporter ZRT1
    NP_011259.1
    • High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      20978..22108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181121.1 → NP_011259.1  TPA: high-affinity Zn(2+) transporter ZRT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011259.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV80, P32804
      UniProtKB/TrEMBL
      G2WDK5
      Conserved Domains (1) summary
      TIGR00820
      Location:31 → 376
      zip; ZIP zinc/iron transport family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32804.1

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