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    gag-pol fusion protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853006, updated on 2-Nov-2024

    Summary

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    Official Full Name
    gag-pol fusion protein
    Primary source
    SGD:S000007347
    Locus tag
    YGR109W-B
    See related
    AllianceGenome:SGD:S000007347; FungiDB:YGR109W-B; VEuPathDB:YGR109W-B
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable several functions, including DNA polymerase activity; RNA nuclease activity; and peptidase activity. Predicted to be involved in retrotransposition. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (707610..712254)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene B-type cyclin CLB6 Neighboring gene tRNA-Cys Neighboring gene gag protein Neighboring gene carboxylic ester hydrolase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes. Abascal-Palacios G, et al. Nat Commun, 2021 Nov 30. PMID 34848735, Free PMC Article
    2. Integrase mediates nuclear localization of Ty3. Lin SS, et al. Mol Cell Biol, 2001 Nov. PMID 11604517, Free PMC Article
    3. Mutating conserved residues in the ribonuclease H domain of Ty3 reverse transcriptase affects specialized cleavage events. Lener D, et al. J Biol Chem, 2002 Jul 19. PMID 11994277
    4. Functional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptase. Bibillo A, et al. Nucleic Acids Res, 2005. PMID 15647500, Free PMC Article
    5. Interaction of the Ty3 reverse transcriptase thumb subdomain with template-primer. Bibillo A, et al. J Biol Chem, 2005 Aug 26. PMID 15944162

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes.
      Title: Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes.
    2. Functional analysis of the triad of conserved aspartic acid residues at the DNA polymerase active site of Ty3 reverse transcriptase (RT).
      Title: Functional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA nuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA-templated DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrotransposition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in retrotransposon nucleocapsid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gag-pol fusion protein
    NP_011624.1
    • Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      707610..712254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184381.2 → NP_011624.1  TPA: gag-pol fusion protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011624.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUP1, Q99315
      Conserved Domains (6) summary
      cd01647
      Location:623 → 797
      RT_LTR; RT_LTR: Reverse transcriptases (RTs) from retrotransposons and retroviruses which have long terminal repeats (LTRs) in their DNA copies but not in their RNA template. RT catalyzes DNA replication from an RNA template, and is responsible for the ...
      pfam03732
      Location:70 → 157
      Retrotrans_gag; Retrotransposon gag protein
      cd09274
      Location:889 → 1008
      RNase_HI_RT_Ty3; Ty3/Gypsy family of RNase HI in long-term repeat retroelements
      pfam00078
      Location:639 → 797
      RVT_1; Reverse transcriptase (RNA-dependent DNA polymerase)
      pfam00665
      Location:1172 → 1280
      rve; Integrase core domain
      cl11403
      Location:286 → 462
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein
    Heading Accession and Version

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