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    RTT102 Rtt102p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853192, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RTT102
    Official Full Name
    Rtt102p
    Primary source
    SGD:S000003507
    Locus tag
    YGR275W
    See related
    AllianceGenome:SGD:S000003507; FungiDB:YGR275W; VEuPathDB:YGR275W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in chromosome segregation; nucleosome disassembly; and transcription elongation from RNA polymerase II promoter. Located in nucleus. Part of RSC-type complex and SWI/SNF complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RTT102 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1043276..1043749)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene histone acetyltransferase Neighboring gene Rnh70p Neighboring gene putative pantetheine-phosphate adenylyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into assembly and function of the RSC chromatin remodeling complex. Baker RW, et al. Nat Struct Mol Biol, 2021 Jan. PMID 33288924, Free PMC Article
    2. Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase. Turegun B, et al. Commun Biol, 2018. PMID 29809203, Free PMC Article
    3. Subunit Rtt102 controls the conformation of the Arp7/9 heterodimer and its interactions with nucleotide and the catalytic subunit of SWI/SNF remodelers. Turegun B, et al. J Biol Chem, 2013 Dec 13. PMID 24189066, Free PMC Article
    4. Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler. Schubert HL, et al. Proc Natl Acad Sci U S A, 2013 Feb 26. PMID 23401505, Free PMC Article
    5. Proteomic analysis of chromatin-modifying complexes in Saccharomyces cerevisiae identifies novel subunits. Lee KK, et al. Biochem Soc Trans, 2004 Dec. PMID 15506919

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a function for subunit Rtt102 as a stabilizing factor for the Arp7/9 heterodime
      Title: Subunit Rtt102 controls the conformation of the Arp7/9 heterodimer and its interactions with nucleotide and the catalytic subunit of SWI/SNF remodelers.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA translocase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RSC-type complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rtt102p
    NP_011791.4
    • Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1043276..1043749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181404.3 → NP_011791.4  TPA: Rtt102p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011791.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV52, P53330
      UniProtKB/TrEMBL
      A6ZUT1, C7GNG0, C8Z9G8, G2WEZ8
      Conserved Domains (1) summary
      pfam09510
      Location:5 → 140
      Rtt102p; Rtt102p-like transcription regulator protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53330.2

    Gene LinkOut

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