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    SCW4 putative family 17 glucosidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853196, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SCW4
    Official Full Name
    putative family 17 glucosidase
    Primary source
    SGD:S000003511
    Locus tag
    YGR279C
    See related
    AllianceGenome:SGD:S000003511; FungiDB:YGR279C; VEuPathDB:YGR279C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in conjugation with cellular fusion. Located in extracellular region; fungal-type cell wall; and vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SCW4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1048798..1049958, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene putative pantetheine-phosphate adenylyltransferase Neighboring gene U2-type spliceosomal complex subunit CWC22 Neighboring gene telomerase inhibitor Neighboring gene ATP-binding cassette transporter YOR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Post-Translational Modifications, Localization, and Mode of Attachment of Non-Covalently Bound Glucanosyltransglycosylases of Yeast Cell Wall as a Key to Understanding their Functioning. Rekstina VV, et al. Int J Mol Sci, 2020 Nov 5. PMID 33167499, Free PMC Article
    2. Adhesion to the yeast cell surface as a mechanism for trapping pathogenic bacteria by Saccharomyces probiotics. Tiago FCP, et al. J Med Microbiol, 2012 Sep. PMID 22580913
    3. A model for cell wall dissolution in mating yeast cells: polarized secretion and restricted diffusion of cell wall remodeling enzymes induces local dissolution. Huberman LB, et al. PLoS One, 2014. PMID 25329559, Free PMC Article
    4. Scw10p, a cell-wall glucanase/transglucosidase important for cell-wall stability in Saccharomyces cerevisiae. Sestak S, et al. Microbiology (Reading), 2004 Oct. PMID 15470100
    5. New potential cell wall glucanases of Saccharomyces cerevisiae and their involvement in mating. Cappellaro C, et al. J Bacteriol, 1998 Oct. PMID 9748433, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteolytic processing by Kex2 of the Saccharomyces cerevisiae cell wall protein Scw4 regulates its activity and influences its covalent binding to glucan.
      Title: Proteolytic processing of the Saccharomyces cerevisiae cell wall protein Scw4 regulates its activity and influences its covalent binding to glucan.
    2. Sec14 function was required for the route followed by Bgl2, whereas trafficking of other secreted proteins, including Hsp150, Cts1, Scw4, Scw10, Exg1, Cis3, and Ygp1, still occurred, indicating Sec14 regulates specific trans-Golgi export pathways.
      Title: Phospholipid transfer protein Sec14 is required for trafficking from endosomes and regulates distinct trans-Golgi export pathways.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glucan endo-1,3-beta-D-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type cell wall IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative family 17 glucosidase
    NP_011795.1
    • Cell wall protein with similarity to glucanases; targeted to vacuole via AP-3 pathway; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog, SCW10, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1048798..1049958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181408.1 → NP_011795.1  TPA: putative family 17 glucosidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011795.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV56, P53334
      UniProtKB/TrEMBL
      A6ZUT5, C7GNF6, G2WF02, N1P465
      Conserved Domains (1) summary
      COG5309
      Location:123 → 386
      Scw11; Exo-beta-1,3-glucanase, GH17 family [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53334.1

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