TNA1 Tna1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: TNA1
Official Full Name: Tna1p
Primary source: SGD:S000003492
Locus tag: YGR260W
See related: AllianceGenome:SGD:S000003492; FungiDB:YGR260W; VEuPathDB:YGR260W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables carboxylic acid transmembrane transporter activity. Involved in quinolinic acid transmembrane transport. Located in cell periphery; fungal-type vacuole; and mitochondrion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 25; gout; porokeratosis; and sialuria. Orthologous to several human genes including SLC17A1 (solute carrier family 17 member 1); SLC17A2 (solute carrier family 17 member 2); and SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables carboxylic acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carboxylic acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in quinolinic acid transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cortical endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

NP_011776.1

High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)

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The following sections contain reference sequences that belong to a specific genome build. Explain