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    PLM2 Plm2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852112, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PLM2
    Official Full Name
    Plm2p
    Primary source
    SGD:S000002909
    Locus tag
    YDR501W
    See related
    AllianceGenome:SGD:S000002909; FungiDB:YDR501W; VEuPathDB:YDR501W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables chromatin binding activity. Involved in DNA damage response. Located in chromatin. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PLM2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1451353..1452918)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Lcd1p Neighboring gene ribosomal 60S subunit protein L37B Neighboring gene methionine adenosyltransferase SAM2 Neighboring gene phosphatidate phosphatase LPP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae. Nautiyal S, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12084816, Free PMC Article
    2. Genotoxicity of chemical compounds identification and assessment by yeast cells transformed with GFP reporter constructs regulated by the PLM2 or DIN7 promoter. Bui VN, et al. Int J Toxicol, 2015 Jan-Feb. PMID 25691521
    3. The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway. Huang M, et al. Cold Spring Harb Symp Quant Biol, 2000. PMID 12760057
    4. Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae. Horak CE, et al. Genes Dev, 2002 Dec 1. PMID 12464632, Free PMC Article
    5. Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases. Tang X, et al. Methods Enzymol, 2005. PMID 16338374

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genotoxicity of chemical compounds identification and assessment by yeast cells transformed with GFP reporter constructs regulated by the PLM2 or DIN7 promoter
      Title: Genotoxicity of chemical compounds identification and assessment by yeast cells transformed with GFP reporter constructs regulated by the PLM2 or DIN7 promoter.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Plm2p
    NP_010789.1
    • Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1451353..1452918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180809.1 → NP_010789.1  TPA: Plm2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010789.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTC3, Q04383
      UniProtKB/TrEMBL
      A6ZZ90, B3LFG6, C8Z658, G2WBM9, N1P7P1
      Conserved Domains (1) summary
      cd00060
      Location:84 → 149
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04383.1

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