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    GIN4 protein kinase GIN4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852119, updated on 3-Nov-2024

    Summary

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    Official Symbol
    GIN4
    Official Full Name
    protein kinase GIN4
    Primary source
    SGD:S000002915
    Locus tag
    YDR507C
    See related
    AllianceGenome:SGD:S000002915; FungiDB:YDR507C; VEuPathDB:YDR507C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ERC47
    Summary
    Enables protein kinase activity. Involved in several processes, including budding cell bud growth; mitotic morphogenesis checkpoint signaling; and septin ring assembly. Located in cellular bud neck. Orthologous to human BRSK1 (BR serine/threonine kinase 1) and BRSK2 (BR serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See GIN4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1462358..1465786, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase Neighboring gene tRNA-Leu Neighboring gene glutamine permease GNP1 Neighboring gene SUMO family protein SMT3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of Cln/Cdc28 regulation of cell morphogenesis in budding yeast. Benton BK, et al. EMBO J, 1993 Dec 15. PMID 8262069, Free PMC Article
    2. Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling. Marquardt J, et al. J Cell Biol, 2024 May 6. PMID 38448162, Free PMC Article
    3. Septin-associated protein kinase Gin4 affects localization and phosphorylation of Chs4, the regulatory subunit of the Baker's yeast chitin synthase III complex. Gohlke S, et al. Fungal Genet Biol, 2018 Aug. PMID 29763674
    4. Septins have a dual role in controlling mitotic exit in budding yeast. Castillon GA, et al. Curr Biol, 2003 Apr 15. PMID 12699621
    5. A positive selection for plasmid loss in Saccharomyces cerevisiae using galactose-inducible growth inhibitory sequences. Kawahata M, et al. Yeast, 1999 Jan 15. PMID 10028180

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling.
      Title: Reciprocal regulation by Elm1 and Gin4 controls septin hourglass assembly and remodeling.
    2. Growth-Dependent Activation of Protein Kinases Suggests a Mechanism for Measuring Cell Growth.
      Title: Growth-Dependent Activation of Protein Kinases Suggests a Mechanism for Measuring Cell Growth.
    3. To identify unknown binding partners of Chs4, we conducted different screening approaches, which yielded several novel candidates of Chs4-binding proteins including the septin-associated kinase Gin4
      Title: Septin-associated protein kinase Gin4 affects localization and phosphorylation of Chs4, the regulatory subunit of the Baker's yeast chitin synthase III complex.
    4. Gin4 is highly localized control of membrane lipid asymmetry and is necessary for optimal cytokinesis.
      Title: Protein kinase Gin4 negatively regulates flippase function and controls plasma membrane asymmetry.
    5. A requirement for the septin Shs1 and the septin-associated kinase Gin4 for the localization and in vivo activity of the budding yeast Bnr1, is described.
      Title: Regulation of the formin Bnr1 by septins anda MARK/Par1-family septin-associated kinase.
    6. Elm1 regulates the septin assembly-dependent cellular events by directly phosphorylating and activating the Gin4-dependent pathway
      Title: Direct phosphorylation and activation of a Nim1-related kinase Gin4 by Elm1 in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in budding cell bud growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in budding cell bud growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic morphogenesis checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization to cell division site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase GIN4
    NP_010795.3
    • Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; negatively regulates Fpk1p kinase that stimulates phospholipid flippases Dnf1p and Dnf2p; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1462358..1465786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180815.3 → NP_010795.3  TPA: protein kinase GIN4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010795.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTC9, Q12263
      UniProtKB/TrEMBL
      B3LFG1, N1P926
      Conserved Domains (2) summary
      cd12194
      Location:1026 → 1139
      Kcc4p_like_C; C-terminal kinase associated domain 1 (KA1), a phospholipid binding domain, of Kcc4p and similar proteins
      cl21453
      Location:17 → 289
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12263.1

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