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    COQ10 ubiquinone-binding protein COQ10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854154, updated on 2-Nov-2024

    Summary

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    Official Symbol
    COQ10
    Official Full Name
    ubiquinone-binding protein COQ10
    Primary source
    SGD:S000005368
    Locus tag
    YOL008W
    See related
    AllianceGenome:SGD:S000005368; FungiDB:YOL008W; VEuPathDB:YOL008W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquinone binding activity. Involved in ubiquinone biosynthetic process. Located in mitochondrial inner membrane. Orthologous to several human genes including COQ10A (coenzyme Q10A). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See COQ10 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (310312..310935)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene rRNA-processing endoribonuclease Neighboring gene ERMES complex subunit MDM12 Neighboring gene Csi2p Neighboring gene DNA topoisomerase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Surface receptors in human lymphocytes]. Nowak J. Pol Arch Med Wewn, 1975 Jul. PMID 50596
    2. The dilemma of diagnosing coenzyme Q(10) deficiency in muscle. Louw R, et al. Mol Genet Metab, 2018 Sep. PMID 29530532
    3. Saccharomyces cerevisiae coq10 null mutants are responsive to antimycin A. Busso C, et al. FEBS J, 2010 Nov. PMID 20875086, Free PMC Article
    4. Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function. Tsui HS, et al. J Lipid Res, 2019 Jul. PMID 31048406, Free PMC Article
    5. COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10. Bradley MC, et al. J Biol Chem, 2020 May 1. PMID 32205446, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10.
      Title: COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10.
    2. We therefore conclude from our data that, to prevent possibly not diagnosing a potential CoQ10 deficiency, the expression of CoQ10 levels in muscle on both CS as well as protein content should be considered.
      Title: The dilemma of diagnosing coenzyme Q(10) deficiency in muscle.
    3. Data suggest that wild-type and coq10 mitochondria accumulate similar amounts of Q(6) semiquinone.
      Title: Saccharomyces cerevisiae coq10 null mutants are responsive to antimycin A.
    4. These results indicate that Coq10p binds Q6 in vivo and that this property is essential for a normal functioning of the electron transport chain.
      Title: Over-expression of COQ10 in Saccharomyces cerevisiae inhibits mitochondrial respiration.
    5. Coq10p is a Q6-binding protein and in the coq10 mutant Q6 it is not able to act as an electron carrier, possibly because of improper localization
      Title: The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular carrier activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquinone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinone-binding protein COQ10
    NP_014635.1
    • Coenzyme Q (ubiquinone) binding protein; functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes; respiratory growth defect of the null mutant is functionally complemented by human COQ10A

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      310312..310935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183262.1 → NP_014635.1  TPA: ubiquinone-binding protein COQ10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014635.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W259, Q08058
      UniProtKB/TrEMBL
      A6ZNJ8, B3LJ48, B5VRP5, C7GJW0, C8ZHV7, G2WMM3, N1NWS8
      Conserved Domains (1) summary
      cl14643
      Location:43 → 196
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08058.1

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