PSD1 phosphatidylserine decarboxylase 1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PSD1
Official Full Name: phosphatidylserine decarboxylase 1
Primary source: SGD:S000005113
Locus tag: YNL169C
See related: AllianceGenome:SGD:S000005113; FungiDB:YNL169C; VEuPathDB:YNL169C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables phosphatidylserine decarboxylase activity. Involved in several processes, including lipid droplet formation; mitochondrial electron transport, ubiquinol to cytochrome c; and positive regulation of mitochondrial fusion. Located in mitochondrial inner membrane. Is active in endoplasmic reticulum membrane. Used to study Parkinson's disease. Orthologous to human PISD (phosphatidylserine decarboxylase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PSD1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (316169..317671, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ER-localized phosphatidylethanolamine synthase plays a conserved role in lipid droplet formation.
Title: ER-localized phosphatidylethanolamine synthase plays a conserved role in lipid droplet formation.
Molecular species selectivity of lipid transport creates a mitochondrial sink for di-unsaturated phospholipids.
Title: Molecular species selectivity of lipid transport creates a mitochondrial sink for di-unsaturated phospholipids.
We also identified a single amino acid polymorphism in PSD1 that causes sensitivity to high temperature in a strain dependent fashion
Title: Genetic Basis of Variation in Heat and Ethanol Tolerance in Saccharomyces cerevisiae.
IM2 is essential for full enzymatic activity, maturation and correct integration of yeast Psd1p into the inner mitochondrial membrane.
Title: Identification and characterization of the mitochondrial membrane sorting signals in phosphatidylserine decarboxylase 1 from Saccharomyces cerevisiae.
Psd1p autocatalysis does not require mitochondrial-specific phospholipids, proteins, or co-factors, because Psd1p re-directed to the secretory pathway undergoes autocatalysis normally and is fully functional in vivo.
Title: Phosphatidylserine decarboxylase 1 autocatalysis and function does not require a mitochondrial-specific factor.
Psd1 promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of Mgm1.
Title: Phosphatidylserine decarboxylase 1 (Psd1) promotes mitochondrial fusion by regulating the biophysical properties of the mitochondrial membrane and alternative topogenesis of mitochondrial genome maintenance protein 1 (Mgm1).
PS is transferred from the mitochondrial outer membrane to the inner membrane independently of Psd1p, Ups1p, and Ups2p and decarboxylated to PE by Psd1p in the inner membrane
Title: Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P.
Membrane integration of Psd1 is crucial for its functionality and for maintenance of mitochondrial lipid homeostasis
Title: Processing and topology of the yeast mitochondrial phosphatidylserine decarboxylase 1.
Overproduction of Psd1 in wild-type ([rho(+)]) cells was found to induce PDR5 transcription and drug resistance in a Pdr3-dependent manner.
Title: Evidence for the bifunctional nature of mitochondrial phosphatidylserine decarboxylase: role in Pdr3-dependent retrograde regulation of PDR5 expression.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine decarboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in glycerophospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid droplet formation	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylethanolamine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoprocessing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylserine decarboxylase 1

NP_014230.1

EC 4.1.1.65

Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology; partly exposed to the mitochondrial intermembrane space; ER-localized fraction is involved in formation of lipid droplets; autocatalytically processed

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

316169..317671 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183007.1 → NP_014230.1 TPA: phosphatidylserine decarboxylase 1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014230.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W113, P39006

UniProtKB/TrEMBL

A6ZRR4, B3LP23, C7GTE6, N1NXB9

Conserved Domains (1) summary

TIGR00163
Location:169 → 495

PS_decarb; phosphatidylserine decarboxylase precursor