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    CSI1 Csi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855040, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CSI1
    Official Full Name
    Csi1p
    Primary source
    SGD:S000004627
    Locus tag
    YMR025W
    See related
    AllianceGenome:SGD:S000004627; FungiDB:YMR025W; VEuPathDB:YMR025W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion and protein deneddylation. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CSI1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (323300..324187)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene mitochondrial 54S ribosomal protein YmL3 Neighboring gene ubiquitin-protein ligase peroxin 12 Neighboring gene putative methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemogenomic study of gemcitabine using Saccharomyces cerevisiae as model cell-molecular insights about chemoresistance. de Sousa Cavalcante L, et al. Braz J Microbiol, 2020 Jun. PMID 31515725, Free PMC Article
    2. Saccharomyces cerevisiae as a Toolkit for COP9 Signalosome Research. Harshuk-Shabso D, et al. Biomolecules, 2021 Mar 25. PMID 33806190, Free PMC Article
    3. The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae. Licursi V, et al. FEBS J, 2014 Jan. PMID 24164706
    4. Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms. Nestoras K, et al. Genes Dev, 2010 Jun 1. PMID 20516199, Free PMC Article
    5. The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes. Maytal-Kivity V, et al. Int J Biochem Cell Biol, 2003 May. PMID 12672462

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Csi1p
    NP_013738.1
    • Subunit of the Cop9 signalosome; which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      323300..324187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182521.1 → NP_013738.1  TPA: Csi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013738.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZJ9, Q04368
      UniProtKB/TrEMBL
      A6ZM87, B3LLS6, B5VPF2, C7GL94, C8ZEN2, N1P5C5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04368.1

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