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    AIM33 cytochrome-b5 reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854887, updated on 28-Oct-2024

    Summary

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    Official Symbol
    AIM33
    Official Full Name
    cytochrome-b5 reductase
    Primary source
    SGD:S000004552
    Locus tag
    YML087C
    See related
    AllianceGenome:SGD:S000004552; FungiDB:YML087C; VEuPathDB:YML087C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R1 (cytochrome b5 reductase 1) and CYB5R3 (cytochrome b5 reductase 3). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See AIM33 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (94431..95369, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SCF ubiquitin ligase complex subunit UFO1 Neighboring gene D-arabinono-1,4-lactone oxidase Neighboring gene alpha-tubulin TUB1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. Heinicke S, et al. PLoS One, 2007 Aug 22. PMID 17712414, Free PMC Article
    2. The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat. Shortill SP, et al. Elife, 2022 Aug 8. PMID 35938928, Free PMC Article
    3. Selective defects in gene expression control genome instability in yeast splicing mutants. Tam AS, et al. Mol Biol Cell, 2019 Jan 15. PMID 30462576, Free PMC Article
    4. Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. Hess DC, et al. PLoS Genet, 2009 Mar. PMID 19300474, Free PMC Article
    5. Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated. Voynova NS, et al. Eukaryot Cell, 2015 Dec. PMID 26432633, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome-b5 reductase
    NP_013623.1
    • hypothetical protein, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      94431..95369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182446.1 → NP_013623.1  TPA: cytochrome-b5 reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013623.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0J6, Q04516
      UniProtKB/TrEMBL
      A6ZLX8, B3LLG9, C7GV72, C8ZEB7
      Conserved Domains (1) summary
      cd06183
      Location:75 → 312
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04516.1

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