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    SAK1 serine/threonine protein kinase SAK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856866, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SAK1
    Official Full Name
    serine/threonine protein kinase SAK1
    Primary source
    SGD:S000000931
    Locus tag
    YER129W
    See related
    AllianceGenome:SGD:S000000931; FungiDB:YER129W; VEuPathDB:YER129W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PAK1
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to glucose starvation; regulation of glycogen biosynthetic process; and regulation of pseudohyphal growth. Located in cytoplasm. Orthologous to human CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SAK1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (417281..420709)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Lcp5p Neighboring gene Vfa1p Neighboring gene Com2p Neighboring gene ribosomal 40S subunit protein S26B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sak1 kinase interacts with Pso2 nuclease in response to DNA damage induced by interstrand crosslink-inducing agents in Saccharomyces cerevisiae. Munari FM, et al. J Photochem Photobiol B, 2014 Jan 5. PMID 24362320
    2. Snf1 kinase complexes with different beta subunits display stress-dependent preferences for the three Snf1-activating kinases. McCartney RR, et al. Curr Genet, 2005 Jun. PMID 15824893
    3. Overexpression of the protein kinase Pak1 suppresses yeast DNA polymerase mutations. Hovland PG, et al. Mol Gen Genet, 1997 Sep. PMID 9341678
    4. Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways. Kim JH, et al. J Biol Chem, 2020 Dec 11. PMID 33060198, Free PMC Article
    5. Regulation of snf1 protein kinase in response to environmental stress. Hong SP, et al. J Biol Chem, 2007 Jun 8. PMID 17438333

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C terminal of the Sak1 mediate interaction with Snf1 and activation of Snf1.
      Title: Interaction of SNF1 protein kinase with its activating kinase Sak1.
    2. Data report for the first time that a constitutively high level of expression of SAK1 alleviates glucose repression and shifts the fermentative/oxidative balance under both glucose-repressed and -derepressed conditions.
      Title: Shifting the fermentative/oxidative balance in Saccharomyces cerevisiae by transcriptional deregulation of Snf1 via overexpression of the upstream activating kinase Sak1p.
    3. Results suggest that Sak1 is involved in nitrogen signaling upstream of Snf1.
      Title: Roles of the Snf1-activating kinases during nitrogen limitation and pseudohyphal differentiation in Saccharomyces cerevisiae.
    4. The purification and characterization of the three Snf1-activating kinases (Sak1, Tos3, and Elm2) of Saccharomyces cerevisiae are reported.
      Title: Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated DNA replication IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein kinase SAK1
    NP_011055.3
    • Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal growth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog, TOS3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      417281..420709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179019.3 → NP_011055.3  TPA: serine/threonine protein kinase SAK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011055.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM35, P38990
      UniProtKB/TrEMBL
      A6ZR83, C7GKX6, C8Z7E6
      Conserved Domains (1) summary
      cd14008
      Location:139 → 448
      STKc_LKB1_CaMKK; Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38990.1

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