MRI1 S-methyl-5-thioribose-1-phosphate isomerase MRI1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MRI1
Official Full Name: S-methyl-5-thioribose-1-phosphate isomerase MRI1
Primary source: SGD:S000006322
Locus tag: YPR118W
See related: AllianceGenome:SGD:S000006322; FungiDB:YPR118W; VEuPathDB:YPR118W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables S-methyl-5-thioribose-1-phosphate isomerase activity. Involved in L-methionine salvage from methylthioadenosine. Located in cytoplasm and nucleus. Orthologous to human MRI1 (methylthioribose-1-phosphate isomerase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MRI1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (767752..768987)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables S-methyl-5-thioribose-1-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-methyl-5-thioribose-1-phosphate isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables S-methyl-5-thioribose-1-phosphate isomerase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-methionine salvage from S-adenosylmethionine	IEA Inferred from Electronic Annotation more info
involved_in L-methionine salvage from methylthioadenosine	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-methionine salvage from methylthioadenosine	IEA Inferred from Electronic Annotation more info
involved_in L-methionine salvage from methylthioadenosine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: S-methyl-5-thioribose-1-phosphate isomerase MRI1

NP_015443.1

EC 5.3.1.23

5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

767752..768987

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184215.1 → NP_015443.1 TPA: S-methyl-5-thioribose-1-phosphate isomerase MRI1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015443.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZWZ9, B3LK82, B5VTQ8, C7GXT0, C8ZJE0, D6W4B7, Q06489

UniProtKB/TrEMBL

N1P2B9

Conserved Domains (1) summary

COG0182
Location:1 → 411

MtnA; Methylthioribose-1-phosphate isomerase (methionine salvage pathway), a paralog of eIF-2B alpha subunit [Amino acid transport and metabolism]