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    Y32H12A.8 WDR59/RTC1-like RING zinc finger domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175742, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Y32H12A.8
    Official Full Name
    WDR59/RTC1-like RING zinc finger domain-containing protein
    Primary source
    WormBase:WBGene00021316
    Locus tag
    CELE_Y32H12A.8
    See related
    AllianceGenome:WB:WBGene00021316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in rRNA processing. Predicted to be part of Seh1-associated complex. Predicted to be active in nucleus. Is expressed in several structures, including nervous system; pharyngeal-intestinal valve; pharynx; reproductive system; and tail. Orthologous to human WDR24 (WD repeat domain 24). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Y32H12A.8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    39
    Sequence:
    Chromosome: III; NC_003281.10 (5385489..5406037, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Flavodoxin-like domain-containing protein Neighboring gene ABC1 atypical kinase-like domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene Protein kinase domain-containing protein Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene J domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Shen X, et al. Cell Calcium, 2008 May. PMID 17854888
    2. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Seh1-associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WDR59/RTC1-like RING zinc finger domain-containing protein
    NP_001360479.1
    • Confirmed by transcript evidence
    NP_001360485.1
    • Confirmed by transcript evidence
    NP_001368729.1
    • Confirmed by transcript evidence
    NP_001368730.1
    • Confirmed by transcript evidence
    NP_498151.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5385489..5406037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379710.2 → NP_001368730.1  WDR59/RTC1-like RING zinc finger domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WV77
      Conserved Domains (3) summary
      sd00039
      Location:110 → 146
      7WD40; WD40 repeat [structural motif]
      cd16691
      Location:791 → 839
      mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
      cl29593
      Location:140 → 364
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_065750.6 → NP_498151.2  WDR59/RTC1-like RING zinc finger domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498151.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N533
      Conserved Domains (3) summary
      sd00039
      Location:106 → 142
      7WD40; WD40 repeat [structural motif]
      cd16691
      Location:787 → 835
      mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
      cl29593
      Location:136 → 360
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001372583.2 → NP_001360479.1  WDR59/RTC1-like RING zinc finger domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WWW2
      Conserved Domains (3) summary
      sd00039
      Location:110 → 146
      7WD40; WD40 repeat [structural motif]
      cd16691
      Location:791 → 839
      mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
      cl29593
      Location:140 → 364
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_001379709.1 → NP_001368729.1  WDR59/RTC1-like RING zinc finger domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WWC7
      Conserved Domains (3) summary
      sd00039
      Location:114 → 150
      7WD40; WD40 repeat [structural motif]
      cl17238
      Location:798 → 841
      RING_Ubox; RING finger (Really Interesting New Gene) domain and U-box domain superfamily
      cl29593
      Location:144 → 368
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. NM_001372585.2 → NP_001360485.1  WDR59/RTC1-like RING zinc finger domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WVA9
      Conserved Domains (3) summary
      sd00039
      Location:106 → 142
      7WD40; WD40 repeat [structural motif]
      cd16691
      Location:787 → 835
      mRING-H2-C3H3C2_Mio; Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and simialr proteins
      cl29593
      Location:136 → 360
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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