Srpx sushi-repeat-containing protein, X-linked [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Srpxprovided by RGD
Official Full Name: sushi-repeat-containing protein, X-linkedprovided by RGD
Primary source: RGD:70950
See related: EnsemblRapid:ENSRNOG00000088892 AllianceGenome:RGD:70950
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Drs
Summary: Predicted to be involved in phagolysosome assembly. Predicted to act upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and response to endoplasmic reticulum stress. Predicted to be located in autophagosome and endoplasmic reticulum. Orthologous to human SRPX (sushi repeat containing protein X-linked). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 89.9), Heart (RPKM 85.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (15349498..15420389)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (12676984..12751296)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (14146618..14220756, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell proliferation involved in contact inhibition	ISO Inferred from Sequence Orthology more info
involved_in phagolysosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phagolysosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sushi repeat-containing protein SRPX

Names: down-regulated by v-src; sushi-repeat-containing protein, X chromosome

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022524.2 → NP_071969.1 sushi repeat-containing protein SRPX precursor

See identical proteins and their annotated locations for NP_071969.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q5PPK5, Q63769

UniProtKB/TrEMBL

A6K020

Related

ENSRNOP00000048924.2, ENSRNOT00000045753.4

Conserved Domains (3) summary

cd00033
Location:262 → 317

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam02494
Location:175 → 257

HYR; HYR domain

pfam13778
Location:332 → 449

DUF4174; Domain of unknown function (DUF4174)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

15349498..15420389

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256683.5 → XP_006256745.1 sushi repeat-containing protein SRPX isoform X1

See identical proteins and their annotated locations for XP_006256745.1

UniProtKB/TrEMBL

A6K020

Related

ENSRNOP00000083955.1, ENSRNOT00000114608.2

Conserved Domains (3) summary

cd00033
Location:242 → 297

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam02494
Location:155 → 237

HYR; HYR domain

pfam13778
Location:312 → 429

DUF4174; Domain of unknown function (DUF4174)