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    Serpina3l serine (or cysteine) peptidase inhibitor, clade A, member 3L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299282, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Serpina3lprovided by RGD
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3Lprovided by RGD
    Primary source
    RGD:3745
    See related
    EnsemblRapid:ENSRNOG00000010478 AllianceGenome:RGD:3745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SPI1; Spin1; CPi-23; Spin2a; Ab1-021
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 11322.8) See more
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    Genomic context

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    See Serpina3l in Genome Data Viewer
    Location:
    6q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (129063145..129079465)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (123298365..123305804)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (128046780..128062241)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene serine protease inhibitor A3B-like Neighboring gene serine (or cysteine) proteinase inhibitor, clade A, member 3C Neighboring gene serpin family A member 3N Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Growth hormone induces two mRNA species of the serine protease inhibitor gene family in rat liver. Yoon JB, et al. J Biol Chem, 1987 Mar 25. PMID 3494016
    2. Accelerated evolution in the reactive centre regions of serine protease inhibitors. Hill RE, et al. Nature, 1987 Mar 5-11. PMID 3493437
    3. Primary structure and assignment to chromosome 6 of three related rat genes encoding liver serine protease inhibitors. Pagès G, et al. Gene, 1990 Oct 15. PMID 2258058
    4. Molecular cloning and characterization of rat contrapsin-like protease inhibitor and related proteins. Ohkubo K, et al. J Biochem, 1991 Feb. PMID 1864837
    5. Molecular characterization of three rat liver serine-protease inhibitors affected by inflammation and hypophysectomy. Protein and mRNA analysis and cDNA cloning. Pages G, et al. Eur J Biochem, 1990 Jun 20. PMID 1694763

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine protease inhibitor A3L
    Names
    SPI-1
    SPI-2.1
    contrapsin-like protease inhibitor 3
    contrapsin-like protease inhibitor-related protein
    liver regeneration protein lrryan
    serine protease inhibitor 1
    serine protease inhibitor 2.1
    serine protease inhibitor 2a
    serpin A3L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389215.2 → NP_001376144.2  serine protease inhibitor A3L precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P05544
      UniProtKB/TrEMBL
      A0A0G2JXK5, A6JEQ7
      Conserved Domains (1) summary
      cd19551
      Location:36 → 413
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      129063145..129079465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261769.1 → XP_063117839.1  serine protease inhibitor A3L isoform X2

    2. XM_039112077.1 → XP_038968005.1  serine protease inhibitor A3L isoform X1

      UniProtKB/Swiss-Prot
      P05544
      UniProtKB/TrEMBL
      A0A0G2JXK5, A6JEQ7
      Conserved Domains (1) summary
      cd19551
      Location:36 → 413
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

    3. XM_039112075.2 → XP_038968003.1  serine protease inhibitor A3L isoform X1

      UniProtKB/Swiss-Prot
      P05544
      UniProtKB/TrEMBL
      A0A0G2JXK5, A6JEQ7
      Related
      ENSRNOP00000070308.2, ENSRNOT00000087017.3
      Conserved Domains (1) summary
      cd19551
      Location:36 → 413
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

    4. XM_039112076.2 → XP_038968004.1  serine protease inhibitor A3L isoform X1

      UniProtKB/Swiss-Prot
      P05544
      UniProtKB/TrEMBL
      A0A0G2JXK5, A6JEQ7
      Conserved Domains (1) summary
      cd19551
      Location:36 → 413
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182474.1: Suppressed sequence

      Description
      NM_182474.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05544.3 GenPept UniProtKB/Swiss-Prot:P05544
    P09005.1 GenPept UniProtKB/Swiss-Prot:P09005

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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