Uqcrh ubiquinol-cytochrome c reductase hinge protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uqcrhprovided by RGD
Official Full Name: ubiquinol-cytochrome c reductase hinge proteinprovided by RGD
Primary source: RGD:1305987
See related: AllianceGenome:RGD:1305987
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRH (ubiquinol-cytochrome c reductase hinge protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 4282.8), Muscle (RPKM 2924.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (134782687..134790882, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (129545978..129554173, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (134919040..134927235, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129777 (e-PCR)
- UniSTS:213069

BE108773 (e-PCR)
- UniSTS:247887

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquinol-cytochrome-c reductase activity	ISO Inferred from Sequence Orthology more info
enables ubiquinol-cytochrome-c reductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex III	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex III	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytochrome b-c1 complex subunit 6, mitochondrial

Names: complex III subunit 6; complex III subunit VIII; cytochrome c1 non-heme 11 kDa protein; mitochondrial hinge protein; ubiquinol-cytochrome c reductase complex 11 kDa protein

NP_001009480.1

EC 7.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009480.1 → NP_001009480.1 cytochrome b-c1 complex subunit 6, mitochondrial

See identical proteins and their annotated locations for NP_001009480.1

Status: PROVISIONAL

Source sequence(s)

BC086954

UniProtKB/Swiss-Prot

Q5M9I5

UniProtKB/TrEMBL

A0A8L2Q828, A6JZ59

Conserved Domains (1) summary

pfam02320
Location:26 → 88

UCR_hinge; Ubiquinol-cytochrome C reductase hinge protein