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    Aga aspartylglucosaminidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290923, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Agaprovided by RGD
    Official Full Name
    aspartylglucosaminidaseprovided by RGD
    Primary source
    RGD:1309646
    See related
    EnsemblRapid:ENSRNOG00000000108 AllianceGenome:RGD:1309646
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity and protein self-association. Predicted to be involved in protein deglycosylation. Located in lysosome. Human ortholog(s) of this gene implicated in aspartylglucosaminuria and lysosomal storage disease. Orthologous to human AGA (aspartylglucosaminidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 321.3), Lung (RPKM 293.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aga in Genome Data Viewer
    Location:
    16p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (45191215..45249537, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (38504661..38516607, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (41222225..41234169, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene nei-like DNA glycosylase 3 Neighboring gene high mobility group protein B1-like Neighboring gene cytochrome b-c1 complex subunit 6, mitochondrial-like Neighboring gene U7 small nuclear RNA Neighboring gene poly(A) binding protein, cytoplasmic 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Co-localization of hydrolytic enzymes with widely disparate pH optima: implications for the regulation of lysosomal pH. Butor C, et al. J Cell Sci, 1995 Jun. PMID 7673341
    2. Comparison of liver glycosylasparaginases from six vertebrates. Tollersrud OK, et al. Biochem J, 1992 Mar 15. PMID 1554372, Free PMC Article
    3. Ser72Pro active-site disease mutation in human lysosomal aspartylglucosaminidase: abnormal intracellular processing and evidence for extracellular activation. Peltola M, et al. Hum Mol Genet, 1996 Jun. PMID 8776587
    4. Molecular cloning, chromosomal assignment, and expression of the mouse aspartylglucosaminidase gene. Tenhunen K, et al. Genomics, 1995 Nov 20. PMID 8586423
    5. Purification and characterization of rat liver glycosylasparaginase. Tollersrud OK, et al. Biochem J, 1989 May 15. PMID 2775174, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112709

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein deglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase
    Names
    N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
    glycosylasparaginase
    NP_001026811.1
    XP_006253173.1
    XP_038950351.1
    XP_038950352.1
    XP_063131333.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031641.1 → NP_001026811.1  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase precursor

      See identical proteins and their annotated locations for NP_001026811.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098718
      UniProtKB/Swiss-Prot
      P30919, Q4G065
      UniProtKB/TrEMBL
      A0A8I5ZKU5, A6JPI4
      Related
      ENSRNOP00000000120.3, ENSRNOT00000000120.5
      Conserved Domains (1) summary
      cd04513
      Location:29 → 331
      Glycosylasparaginase; Glycosylasparaginase and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      45191215..45249537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275263.1 → XP_063131333.1  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X2

      Related
      ENSRNOP00000078440.2, ENSRNOT00000116014.2

    2. XM_006253111.5 → XP_006253173.1  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZKU5, A0A8I6AL08
      Related
      ENSRNOP00000093756.1, ENSRNOT00000107358.2
      Conserved Domains (1) summary
      cd04513
      Location:29 → 350
      Glycosylasparaginase; Glycosylasparaginase and similar proteins

    3. XM_039094423.2 → XP_038950351.1  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X3

      UniProtKB/TrEMBL
      A6JPI5
      Conserved Domains (1) summary
      cd04513
      Location:1 → 235
      Glycosylasparaginase; Glycosylasparaginase and similar proteins

    4. XM_039094424.2 → XP_038950352.1  N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X3

      UniProtKB/TrEMBL
      A6JPI5
      Conserved Domains (1) summary
      cd04513
      Location:1 → 235
      Glycosylasparaginase; Glycosylasparaginase and similar proteins

    RNA

    1. XR_010058288.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30919.2 GenPept UniProtKB/Swiss-Prot:P30919

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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