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    Sec14l2 SEC14-like lipid binding 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116486, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sec14l2provided by RGD
    Official Full Name
    SEC14-like lipid binding 2provided by RGD
    Primary source
    RGD:621779
    See related
    EnsemblRapid:ENSRNOG00000004672 AllianceGenome:RGD:621779
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spf
    Summary
    Enables enzyme activator activity and transferase activity, transferring alkyl or aryl (other than methyl) groups. Involved in positive regulation of cholesterol biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human SEC14L2 (SEC14 like lipid binding 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 499.5), Brain (RPKM 140.6) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sec14l2 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83197384..83222059, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78973805..78998480, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (84335594..84360354, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene SEC14-like lipid binding 3 Neighboring gene uncharacterized LOC102549281 Neighboring gene mitochondrial fission process 1 Neighboring gene ring finger protein 215 Neighboring gene uncharacterized LOC134481866 Neighboring gene coiled-coil domain containing 157

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Supernatant protein factor requires phosphorylation and interaction with Golgi to stimulate cholesterol synthesis in hepatoma cells. Mokashi V, et al. Arch Biochem Biophys, 2005 Mar 1. PMID 15680919
    2. Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro. Mokashi V, et al. Arch Biochem Biophys, 2005 Jan 15. PMID 15581604
    3. Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues. Liu J, et al. Mol Omics, 2021 Jun 14. PMID 34008672
    4. Tocopherol-associated protein is a ligand-dependent transcriptional activator. Yamauchi J, et al. Biochem Biophys Res Commun, 2001 Jul 13. PMID 11444841
    5. Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. Shibata N, et al. Proc Natl Acad Sci U S A, 2001 Feb 27. PMID 11226224, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues.
      Title: Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues.
    2. Sec14l2 stimulates HMG-CoA reductase in hepatoma cell cultures.
      Title: Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro.
    3. overexpression of SEC14L1 modestly decreases high affinity choline transport activity
      Title: SEC14-like protein 1 interacts with cholinergic transporters.
    4. The activation of SPF by PKA suggests that cholesterol synthesis can be rapidly modulated in response to external stimuli by changes in cAMP levels, and that this regulation is dependent on an as yet undefined interaction with Golgi.
      Title: Supernatant protein factor requires phosphorylation and interaction with Golgi to stimulate cholesterol synthesis in hepatoma cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cholesterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SEC14-like protein 2
    Names
    TAP
    alpha-tocopherol-associated protein
    squalene transfer protein
    supernatant protein factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053801.2 → NP_446253.2  SEC14-like protein 2

      See identical proteins and their annotated locations for NP_446253.2

      Status: PROVISIONAL

      Source sequence(s)
      BC089785
      UniProtKB/TrEMBL
      F7F3C3, Q5EBD0
      Related
      ENSRNOP00000006542.5, ENSRNOT00000006542.6
      Conserved Domains (2) summary
      smart00516
      Location:76 → 244
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:13 → 59
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      83197384..83222059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251154.5 → XP_006251216.1  SEC14-like protein 2 isoform X1

      UniProtKB/TrEMBL
      F7F3C3
      Conserved Domains (1) summary
      smart00516
      Location:22 → 190
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

    2. XM_039091558.2 → XP_038947486.1  SEC14-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ADK3
      Conserved Domains (2) summary
      smart00516
      Location:76 → 244
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:13 → 59
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MS0.1 GenPept UniProtKB/Swiss-Prot:Q99MS0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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