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    Osbpl8 oxysterol binding protein-like 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314824, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Osbpl8provided by RGD
    Official Full Name
    oxysterol binding protein-like 8provided by RGD
    Primary source
    RGD:1561474
    See related
    EnsemblRapid:ENSRNOG00000026962 AllianceGenome:RGD:1561474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561474
    Summary
    Predicted to enable several functions, including cholesterol binding activity; phosphatidylserine transfer activity; and phospholipid binding activity. Predicted to be involved in several processes, including activation of protein kinase B activity; negative regulation of sequestering of triglyceride; and positive regulation of glucose import. Predicted to act upstream of or within negative regulation of cell migration; positive regulation of signal transduction; and protein localization to nuclear pore. Predicted to be located in cortical endoplasmic reticulum and nuclear membrane. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Orthologous to human OSBPL8 (oxysterol binding protein like 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 284.0), Thymus (RPKM 187.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osbpl8 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (48483259..48636151)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (46596944..46749888)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (53878906..54030110)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093585 Neighboring gene uncharacterized LOC134479684 Neighboring gene U6 spliceosomal RNA Neighboring gene spindle apparatus coiled-coil protein 1, pseudogene 1 Neighboring gene uncharacterized LOC120093586 Neighboring gene uncharacterized LOC134479686 Neighboring gene eukaryotic translation initiation factor 5, pseudogene 8 Neighboring gene Bardet-Biedl syndrome 10 Neighboring gene uncharacterized LOC102548498 Neighboring gene uncharacterized LOC134479687

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts. Chung J, et al. Science, 2015 Jul 24. PMID 26206935, Free PMC Article
    2. Activin A impairs insulin action in cardiomyocytes via up-regulation of miR-143. Blumensatt M, et al. Cardiovasc Res, 2013 Nov 1. PMID 23812417
    3. Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity. Béaslas O, et al. Exp Cell Res, 2012 Sep 10. PMID 22683860
    4. OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype. Zhou Y, et al. PLoS One, 2012. PMID 23028956, Free PMC Article
    5. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Jordan SD, et al. Nat Cell Biol, 2011 Apr. PMID 21441927

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cortical endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cortical endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309455.2 → NP_001296384.1  oxysterol-binding protein-related protein 8

      See identical proteins and their annotated locations for NP_001296384.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JXN8, A0A8I6A2N1, A6IGF8
      Related
      ENSRNOP00000085965.2, ENSRNOT00000097311.2
      Conserved Domains (3) summary
      cd13286
      Location:141 → 270
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:148 → 264
      PH; PH domain
      pfam01237
      Location:406 → 744
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      48483259..48636151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263481.1 → XP_063119551.1  oxysterol-binding protein-related protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A2N1, A6IGG0
      Related
      ENSRNOP00000079217.1, ENSRNOT00000112719.2

    2. XM_017594846.3 → XP_017450335.1  oxysterol-binding protein-related protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ADC9, A0A8I6GDH8
      Related
      ENSRNOP00000085930.1, ENSRNOT00000100604.2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108093.1: Suppressed sequence

      Description
      NM_001108093.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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