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    Rnft2 ring finger protein, transmembrane 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304521, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Rnft2provided by RGD
    Official Full Name
    ring finger protein, transmembrane 2provided by RGD
    Primary source
    RGD:1560195
    See related
    EnsemblRapid:ENSRNOG00000001124 AllianceGenome:RGD:1560195
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tmem118; RGD1560195
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of ERAD pathway and protein ubiquitination. Predicted to be integral component of membrane. Orthologous to human RNFT2 (ring finger protein, transmembrane 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 96.3) and Testes (RPKM 6.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnft2 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (43990113..44048215)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (38329217..38387303)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (43940929..44008685)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene SREBF pathway regulator in golgi 1 Neighboring gene uncharacterized LOC102553921 Neighboring gene harakiri, BCL2 interacting protein Neighboring gene U6 spliceosomal RNA Neighboring gene F-box and WD repeat domain containing 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNFT2
    Names
    RING finger and transmembrane domain-containing protein 2
    transmembrane protein 118

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107144.2 → NP_001100614.1  E3 ubiquitin-protein ligase RNFT2

      See identical proteins and their annotated locations for NP_001100614.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J1L9, A6J1M0, D3ZTN5
      Conserved Domains (2) summary
      cd00162
      Location:385 → 422
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl17238
      Location:384 → 423
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      43990113..44048215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089494.2 → XP_038945422.1  E3 ubiquitin-protein ligase RNFT2 isoform X2

    2. XM_063271344.1 → XP_063127414.1  E3 ubiquitin-protein ligase RNFT2 isoform X1

      UniProtKB/TrEMBL
      A6J1L9, A6J1M0, D3ZTN5
      Related
      ENSRNOP00000001486.7, ENSRNOT00000001486.9

    3. XM_039089493.2 → XP_038945421.1  E3 ubiquitin-protein ligase RNFT2 isoform X1

      UniProtKB/TrEMBL
      A6J1L9, A6J1M0, D3ZTN5
      Conserved Domains (2) summary
      cd00162
      Location:385 → 422
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl17238
      Location:384 → 423
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_039089492.2 → XP_038945420.1  E3 ubiquitin-protein ligase RNFT2 isoform X1

      UniProtKB/TrEMBL
      A6J1L9, A6J1M0, D3ZTN5
      Conserved Domains (2) summary
      cd00162
      Location:385 → 422
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl17238
      Location:384 → 423
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version

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