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    Fbxl7 F-box and leucine-rich repeat protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361907, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Fbxl7provided by RGD
    Official Full Name
    F-box and leucine-rich repeat protein 7provided by RGD
    Primary source
    RGD:1305813
    See related
    EnsemblRapid:ENSRNOG00000024433 AllianceGenome:RGD:1305813
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to be located in centrosome. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL7 (F-box and leucine rich repeat protein 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 22.5), Heart (RPKM 17.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxl7 in Genome Data Viewer
    Location:
    2q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (78870236..79239697, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (77139775..77509223, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (79067907..79439987, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485864 Neighboring gene membrane associated ring-CH-type finger 11 Neighboring gene uncharacterized LOC120100752 Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 10 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest. Coon TA, et al. Cell Cycle, 2012 Feb 15. PMID 22306998, Free PMC Article
    2. The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin. Liu Y, et al. J Biol Chem, 2015 May 8. PMID 25778398, Free PMC Article
    3. Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. Kamran M, et al. Oncogenesis, 2017 Feb 20. PMID 28218735, Free PMC Article
    4. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108545.1 → NP_001102015.1  F-box/LRR-repeat protein 7

      See identical proteins and their annotated locations for NP_001102015.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473992
      UniProtKB/TrEMBL
      A6JMX5, F1M6W6
      Related
      ENSRNOP00000033571.7, ENSRNOT00000031170.8
      Conserved Domains (3) summary
      cd09293
      Location:297 → 464
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:240 → 273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:114 → 160
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      78870236..79239697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102576.1 → XP_038958504.1  F-box/LRR-repeat protein 7 isoform X1

      Conserved Domains (3) summary
      cd09293
      Location:250 → 417
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:193 → 226
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:67 → 110
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version

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