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    Clint1 clathrin interactor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360515, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Clint1provided by RGD
    Official Full Name
    clathrin interactor 1provided by RGD
    Primary source
    RGD:1303328
    See related
    EnsemblRapid:ENSRNOG00000005406 AllianceGenome:RGD:1303328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Enth; Epn4; Clint
    Summary
    Enables clathrin binding activity. Involved in clathrin coat assembly. Located in clathrin-coated vesicle. Orthologous to human CLINT1 (clathrin interactor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 199.1), Adrenal (RPKM 129.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clint1 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (30799936..30854513)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (30298618..30353185)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (30833914..31007813)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480682 Neighboring gene uncharacterized LOC120095082 Neighboring gene LSM11, U7 small nuclear RNA associated Neighboring gene tRNA-histidine guanylyltransferase 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The clathrin interacting protein Clint/epsinR in rat testicular germ cells. Redecker P. Histochem Cell Biol, 2005 Jun. PMID 15875209
    2. Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. Wasiak S, et al. J Cell Biol, 2002 Sep 2. PMID 12213833, Free PMC Article
    3. Clint: a novel clathrin-binding ENTH-domain protein at the Golgi. Kalthoff C, et al. Mol Biol Cell, 2002 Nov. PMID 12429846, Free PMC Article
    4. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
    5. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clint/epsinR/enthoprotin has been identified in the Golgi region of spermatocytes.
      Title: The clathrin interacting protein Clint/epsinR in rat testicular germ cells.
    2. a novel clathrin-associated protein - enthoprotin ((Enth) identified through subcellular proteomics; data suggest a role in clathrin-mediated budding on internal membranes.
      Title: Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables clathrin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables clathrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin coat assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    clathrin interactor 1
    Names
    enthoprotin
    epsin 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415157.1 → NP_001402086.1  clathrin interactor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5Y9G0
      Related
      ENSRNOP00000069793.3, ENSRNOT00000079437.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      30799936..30854513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767689.3 → XP_008765911.2  clathrin interactor 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JW94, A0A8I5Y9G0
      Conserved Domains (2) summary
      pfam09606
      Location:507 → 634
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd16989
      Location:24 → 149
      ENTH_EpsinR; Epsin N-Terminal Homology (ENTH) domain of Epsin-related protein
    Nucleotide Protein Strain
    Heading Accession and Version

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