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    Trmt1l tRNA methyltransferase 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304851, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Trmt1lprovided by RGD
    Official Full Name
    tRNA methyltransferase 1-likeprovided by RGD
    Primary source
    RGD:1307890
    See related
    EnsemblRapid:ENSRNOG00000002580 AllianceGenome:RGD:1307890
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trm1l; RGD1307890
    Summary
    Predicted to enable tRNA (guanine-N2-)-methyltransferase activity. Predicted to be involved in tRNA N2-guanine methylation. Predicted to act upstream of or within adult locomotory behavior. Predicted to be active in nucleus. Orthologous to human TRMT1L (tRNA methyltransferase 1 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 131.3), Thymus (RPKM 119.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trmt1l in Genome Data Viewer
    Location:
    13q21
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (66060186..66093247)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (63510097..63543268)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (68785889..68819018)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene influenza virus NS1A binding protein Neighboring gene SWT1 RNA endoribonuclease homolog Neighboring gene ring finger protein 2 Neighboring gene small ribosomal subunit protein uS3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour. Vauti F, et al. Gene, 2007 Mar 15. PMID 17198746
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124643

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (guanine(10)-N2)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within adult locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA N2-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TRMT1-like protein
    Names
    TRM1 tRNA methyltransferase 1-like
    TRM1-like protein
    tRNA methyltransferase 1 homolog-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037192.1 → NP_001032269.1  TRMT1-like protein

      See identical proteins and their annotated locations for NP_001032269.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100650
      UniProtKB/Swiss-Prot
      Q496Z9
      UniProtKB/TrEMBL
      A0A8I5ZWS2
      Related
      ENSRNOP00000082306.1, ENSRNOT00000094165.2
      Conserved Domains (2) summary
      cl17173
      Location:244 → 683
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cl22851
      Location:153 → 198
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      66060186..66093247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598807.3 → XP_017454296.1  TRMT1-like protein isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:95 → 534
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_006249992.5 → XP_006250054.1  TRMT1-like protein isoform X1

      See identical proteins and their annotated locations for XP_006250054.1

      UniProtKB/TrEMBL
      A0A8I5ZWS2, A6ICS6
      Related
      ENSRNOP00000104439.1, ENSRNOT00000134317.1
      Conserved Domains (2) summary
      cl17173
      Location:246 → 685
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cl22851
      Location:155 → 200
      PHD_SF; PHD finger superfamily

    3. XM_006249993.5 → XP_006250055.1  TRMT1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWS2
      Related
      ENSRNOP00000003517.8, ENSRNOT00000003517.9
      Conserved Domains (2) summary
      cl17173
      Location:246 → 664
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
      cl22851
      Location:155 → 200
      PHD_SF; PHD finger superfamily

    4. XM_063272317.1 → XP_063128387.1  TRMT1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZWS2, A0A8L2Q0A9

    5. XM_063272318.1 → XP_063128388.1  TRMT1-like protein isoform X4

    6. XM_039090733.1 → XP_038946661.1  TRMT1-like protein isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:16 → 419
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    7. XM_039090734.1 → XP_038946662.1  TRMT1-like protein isoform X6

      Conserved Domains (1) summary
      cl17173
      Location:10 → 402
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RNA

    1. XR_005492245.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q496Z9.1 GenPept UniProtKB/Swiss-Prot:Q496Z9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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