Nptn neuroplastin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nptnprovided by RGD
Official Full Name: neuroplastinprovided by RGD
Primary source: RGD:620296
See related: EnsemblRapid:ENSRNOG00000009029 AllianceGenome:RGD:620296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SDR-1; Sdfr1
Summary: Enables cell adhesion molecule binding activity; transmembrane transporter binding activity; and type 1 fibroblast growth factor receptor binding activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; modulation of chemical synaptic transmission; and positive regulation of signal transduction. Located in several cellular components, including cell surface; inhibitory synapse; and presynaptic membrane. Is active in several cellular components, including GABA-ergic synapse; Schaffer collateral - CA1 synapse; and synaptic membrane. Orthologous to human NPTN (neuroplastin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 771.0), Heart (RPKM 500.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (67892678..67959231)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (58996873..59063402)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (63379062..63445694)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

neuroplastins act as key ancillary proteins for MCT2 cell surface localisation and activity in some neuronal populations, thus playing an important role in facilitating the uptake of lactate for use as a respiratory fuel.
Title: The neuroplastin adhesion molecules are accessory proteins that chaperone the monocarboxylate transporter MCT2 to the neuronal cell surface.
neuroplastin-65 can co-localize with a subset of GABA(A) receptor subtypes and might contribute to anchoring and/or confining GABA(A) receptors to particular synaptic or extra-synaptic sites, thus affecting receptor mobility and synaptic strength
Title: The cell adhesion molecule neuroplastin-65 is a novel interaction partner of γ-aminobutyric acid type A receptors.
Identified the homophilic binding site in Np65 and demonstrated the importance of homophilic interactions in biological responses such as neurite extension and calcium transients in vitro and in an animal model of learning and memory.
Title: Neuroplastin-65 and a mimetic peptide derived from its homophilic binding site modulate neuritogenesis and neuronal plasticity.
both Np55 and the narpin peptide induce neurite outgrowth through FGFR1 activation and that Np55 increases synaptic calcium concentration in an FGFR1-dependent manner.
Title: Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_21804-21805:1025095690:1 (e-PCR)
- UniSTS:268634

UniSTS:236151 (e-PCR)
- UniSTS:236151

RH137991 (e-PCR)
- UniSTS:220078

AW554172 (e-PCR)
- UniSTS:179920

47.MMHAP30FLH5.seq (e-PCR)
- UniSTS:124650

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 1 fibroblast growth factor receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in excitatory synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within excitatory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell adhesion	TAS Traceable Author Statement more info	PubMed
involved_in regulation of receptor localization to synapse	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of receptor localization to synapse	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in visual learning	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	IEA Inferred from Electronic Annotation more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	TAS Traceable Author Statement more info	PubMed
is_active_in presynaptic active zone membrane	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neuroplastin

Names: glycoprotein 55; glycoprotein 55/65; glycoprotein 65; gp55/65; stromal cell derived factor receptor 1; stromal cell-derived receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001413347.1 → NP_001400276.1 neuroplastin isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8L2Q5B1, A6J511

Related

ENSRNOP00000012091.7, ENSRNOT00000012091.9
NM_001413348.1 → NP_001400277.1 neuroplastin isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6J512

Related

ENSRNOP00000012295.5, ENSRNOT00000012295.8
NM_001413349.1 → NP_001400278.1 neuroplastin isoform 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_019380.3 → NP_062253.1 neuroplastin isoform 2 precursor

See identical proteins and their annotated locations for NP_062253.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P97546, P97547, Q6IRE8

UniProtKB/TrEMBL

A6J510

Related

ENSRNOP00000105040.1, ENSRNOT00000140093.1

Conserved Domains (2) summary

cd00096
Location:32 → 36

Ig; Ig strand A [structural motif]

cl11960
Location:31 → 146

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

67892678..67959231

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266041.1 → XP_063122111.1 neuroplastin isoform X1
XM_039082020.2 → XP_038937948.1 neuroplastin isoform X2

UniProtKB/TrEMBL

A6J510

Conserved Domains (2) summary

cd00096
Location:32 → 36

Ig; Ig strand A [structural motif]

cl11960
Location:31 → 146

Ig; Immunoglobulin domain